Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name Sort ascending	PI Organization	Title	Grant Number	Program Official
Peppone, Luke Joseph	University Of Rochester United States	High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients	5R01CA258349-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Penedo, Frank J	University Of Miami Coral Gables United States	eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant Patients	4R33CA263335-03	Asad Umar, D.V.M., Ph.D.
Paus, Ralf	University Of Miami School Of Medicine United States	Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia	1R21CA277418-01A1	Rachel Altshuler, Ph.D.
Panigrahy, Dipak	Beth Israel Deaconess Medical Center United States	Control of cancer cachexia via stimulation of resolution of inflammation	5R01CA276107-03	Marjorie Perloff, M.D.
Palesh, Oxana G	Virginia Commonwealth University United States	Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia	5R01CA239714-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Nelson, Randy J.	West Virginia University United States	Mechanism Underlying Sleep Disruption by Mammary Tumors	5R21CA276027-02	Marjorie Perloff, M.D.
Mosher, Catherine E	Indiana University Indianapolis United States	Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer	5R01CA289486-02
Morin, Olivier	University Of California, San Francisco United States	Development of a Personalized Voxel-wise Prediction of Brain Metastases using Multi-Parametric MR Imaging to Reduce Treatment Toxicity	1R01CA292043-01A1	Marjorie Perloff, M.D.
Morilak, David A	University Of Texas Hlth Science Center United States	Therapy-induced cognitive impairment in a rat model of prostate cancer	5R01CA285183-03	John Clifford, Ph.D.
Milbury, Kathrin	University Of Tx Md Anderson Can Ctr United States	Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers	4R37CA231522-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Melemedjian, Ohannes Kevork	University Of Maryland Baltimore United States	Identification of novel targets for the treatment of chemotherapy-induced painful peripheral neuropathy	4R01CA249939-02	Rachel Altshuler, Ph.D.
Mehrara, Babak J	Sloan-Kettering Inst Can Research United States	Mechanisms of racial disparity in breast cancer-related lymphedema	5R01CA278599-04	Asad Umar, D.V.M., Ph.D.
Meghani, Salimah H.	University Of Pennsylvania United States	Cannabis use and outcomes in ambulatory patients with cancer: A 12-month cohort study	3R01CA270483-04S1	Gabriela Riscuta, M.D., CNS
Mclouth, Laurie	University Of Kentucky United States	Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment	5R01CA283929-03	Brennan Streck, Ph.D., RN, M.P.H.
Marker, Ryan J	University Of Colorado Denver United States	Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation	5R01CA292482-02	Goli Samimi, Ph.D., M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer	Duloxetine, Duloxetine Hydrochloride, Oxaliplatin, Placebo, Quality-of-Life Assessment, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Active, not recruiting
E-Mindfulness Approaches for Living After Breast Cancer	Meditation Only Control Group, Mindfulness (MAPs) Digital App, Mindfulness (MAPs) Live Online	NRG Oncology	Recruiting
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment	Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration	Children's Oncology Group	Recruiting
Engage Psychosocial Intervention for Cancer Symptoms	ENGAGE, Supportive Care	Duke University	Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors	Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT	Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection	University of California, San Francisco	Recruiting
Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment	Quality-of-Life Assessment, Questionnaire Administration	ECOG-ACRIN Cancer Research Group	Active, not recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors	Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer	Androgen deprivation therapy, Flibanserin 100 MG, Placebo	Andrew McDonald	Active, not recruiting
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors	Laboratory Biomarker Analysis, Questionnaire Administration	Children's Oncology Group	Active, not recruiting