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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Bryan, Angela

University Of Colorado
United States

Cannabis for Palliative Care in Cancer: A Placebo-controlled Randomized Trial of Full Spectrum Hemp-derived CBD/THC 5R01CA284860-03 Brennan Streck, Ph.D., RN, M.P.H.
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.
Winters-Stone, Kerri M

Oregon Health & Science University
United States

Patterns and predictors of symptoms, falls, and functioning across treatment and recovery in patients treated with neurotoxic chemotherapy for cancer 5R01CA248059-05 Goli Samimi, Ph.D., M.P.H.
Storz, Peter

Mayo Clinic Jacksonville
United States

Deiminated molecules as markers for developing pancreatic cancer - A1 5R21CA279916-02 Matthew Young, Ph.D.
Panigrahy, Dipak

Beth Israel Deaconess Medical Center
United States

Control of cancer cachexia via stimulation of resolution of inflammation 5R01CA276107-03 Marjorie Perloff, M.D.
Buczynski, Matthew Wallace

Virginia Polytechnic Inst And St Univ
United States

Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathy 5R01CA284075-03 Rachel Altshuler, Ph.D.
Acharya, Munjal M

University Of California-Irvine
United States

Stem cell-derived exosomes to ameliorate chemobrain 5R01CA262213-03 Rachel Altshuler, Ph.D.
Chan, Alexandre

University Of California-Irvine
United States

Neurotrophic strategy to mitigate chemotherapy-related brain injury 5R01CA276212-03 John Clifford, Ph.D.
Paus, Ralf

University Of Miami School Of Medicine
United States

Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia 1R21CA277418-01A1 Rachel Altshuler, Ph.D.
Ross, Stephen

New York University School Of Medicine
United States

Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress 5R01CA268521-04 Rachel Altshuler, Ph.D.
Afshar-Kharghan, Vahid

University Of Tx Md Anderson Can Ctr
United States

Novel Biomarkers Predicting Blood Clots in Ovarian Cancer 5R01CA275762-03 Rachel Altshuler, Ph.D.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Goode, Diana J

University Of New England
United States

Novel expression of MHC class II on DRG neurons and its role in promoting antinociceptive CD4+ T cells in females during chemotherapy-induced peripheral neuropathy 5R01CA267554-04 Rachel Altshuler, Ph.D.
Johnson, Constance Margaret

University Of Texas Hlth Sci Ctr Houston
United States

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy 3R01CA245054-05S1 Rachel Altshuler, Ph.D.

Clinical Trials

Status
Title Intervention Sponsor Status
Reproductive Health Program in Patients With Cancer Standard practice related to reproductive heath, Training modules, algorithm, referral development ECOG-ACRIN Cancer Research Group Active, not recruiting
A Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS) anastrozole ECOG-ACRIN Cancer Research Group Active, not recruiting
Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer metformin hydrochloride, placebo Alliance for Clinical Trials in Oncology Active, not recruiting
Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer Adaptation of IMCP for Chinese Immigrant Cancer Patients, In-depth Patient Interviews, Individual Meaning-Centered Psychotherapy for Chinese (IMCP-Ch) (For Phase 3 and Phase 4) Memorial Sloan Kettering Cancer Center Active, not recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer Endocrine therapy interruption ETOP IBCSG Partners Foundation Active, not recruiting
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Lactobacillus plantarum strain 299, Lactobacillus plantarum strain 299v, Placebo Administration Children's Oncology Group Active, not recruiting
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment Children's Oncology Group Active, not recruiting
Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer Educational Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis, Medical Device Usage and Evaluation, Quality-of-Life Assessment, Questionnaire Administration Children's Oncology Group Active, not recruiting
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia Laboratory Biomarker Analysis, Simplified Patient Care Strategy ECOG-ACRIN Cancer Research Group Active, not recruiting
Dexamethasone in Controlling Dyspnea in Patients With Cancer Dexamethasone, Questionnaire Administration, Placebo M.D. Anderson Cancer Center Active, not recruiting