Siteman Cancer Center Catchment CSRN ACCESS Hub

To bring rigor and broad representation to research and practice of cancer screening and early detection, and to effectively participate in the NCI Cancer Screening Research Network (CSRN), we will build a CSRN ACCESS Hub at Siteman Cancer Center. Improving early detection is critical to reducing the growing burden of cancer and has the potential to save lives in all communities. For this to happen, we must perform research that reaches a range of geographic areas and settings, including rural and urban. Research conducted at the Siteman Catchment Hub will prioritize rigor and representation by collaborating with community-based healthcare systems in Missouri and Illinois. Led by an experienced multi-disciplinary team, our time-tested administrative structure engages participating sites, community partners, community-based clinicians, and institutional expertise. We draw on the deep clinical research infrastructure and support at Siteman Cancer Center and Washington University School of Medicine, and organized our Hub into four cores: Administrative, Participant Engagement, Study Protocol, and Data Quality. We are founded on intentional integration, engagement, and transparent communication. The specific aims of our Hub are: (1) Contribute to the scientific development of CSRN research including an initial Multi-Cancer Detection Vanguard study; (2) Recruit and retain participants to CSRN studies; and (3) Implement CSRN protocols as indicated by the Network. Building on our experience, we propose to enroll 2000 participants across our region into the Vanguard study. We will work closely with community partners to support recruitment and ensure protocols are accessible, acceptable, and of the highest scientific merit. The Siteman Catchment Hub has several notable strengths and innovations: 1) we serve and are committed to populations that reside in health professional shortage areas; 2) our multidisciplinary leadership team has deep experience with cancer screening research, clinical trials, and recruiting and retaining research participants; 3) we engage regional organizational partners and community partners in Hub leadership; 3) we have strong institutional support and infrastructure that will support the conduct of CSRN research, access to quality data, and rigor in our approach. We need sound evidence to inform advances in cancer screening and early detection. The Siteman Catchment CSRN Hub will deliver on that need and engage fully in the Network.