Program Official
Principal Investigator
Lucile Lauren
Adams-Campbell
Awardee Organization
Georgetown University
United States
Fiscal Year
2024
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date
NIH RePORTER
For more information, see NIH RePORTER Project 5UG1CA239758-06
National Capital Area (NCA) Minority/Underserved NCORP
The National Capital Area (NCA) Minority/Underserved NCORP will be based at Georgetown Lombardi Comprehensive Cancer Center (LCCC), comprising Medstar Georgetown University Hospital (MGUH) and MedStar Washington Hospital Center (MWHC) as the primary affiliate, with a catchment area comprising 48.3% non-Latino Blacks (NLB) and 10.6% Hispanics/Latinos (H/L) that includes Washington, D.C. and adjacent counties in Maryland and Virginia. MWHC serves predominantly, i.e., > 85% minority and underserved populations; and treats more than 2,000 predominantly minority cancer patients and 48,000 outpatients, annually. The cancer burden and disparities are greatest among NLB population in the catchment area as evident by some of the highest mortality rates in the nation for breast, prostate, and colorectal cancers. Among the H/L population, cancer is the leading cause of death with H/L patients typically presenting at a later stage compared to Non-Latino White (NLW) patients. High rates of preventable cancer risk factors such as obesity, physical inactivity, and smoking, coupled with much lower screening rates for certain cancers, such as colorectal and cervical cancers in minorities contribute to the cancer disparities seen in the catchment area. The NCA NCORP proposes to address one of the most significant factors associated with these cancer disparities - limited access to optimal and cutting edge prevention, cancer control, and cancer care delivery by increasing awareness and providing access to cancer clinical trials among NLB and H/L in the catchment area. LCCC’s Office of Minority Health and Health Disparities Research (OMH), represents the community outreach arm that is led by Dr. Adams-Campbell, that has established viable academic-community partnerships that enable the NCA NCORP to conduct clinical research in areas of prevention, control, screening, health disparities, and cancer care delivery among the minority populations of interest. In light of an aging population and the increasing number of cancer survivors, this NCORP has the expertise and leadership as evident by demonstrable research in these areas that address cancer control and patient centered cancer care delivery. Furthermore, the ability to address cancer prevention and control among adolescents and young adults (AYA) is also a key strength of our team. The NCA NCORP will address the needs of our catchment area via cancer prevention, control, screening as well as treatment and imaging studies. The specific aims of the proposed National Capital Area NCORP are to: (1) Design and participate in clinical trials in cancer clinical research that improves the quality of care and the health outcomes of the US population in our catchment area; (2) Increase the participation of the greater DC area’s community oncologists and medical specialists and their patients in NCORP-led clinical research; and (3) Expand health disparities research focused on clinical research participation via community outreach, engagement, and education.
Publications
- Streck JM, Lee JW, Walter AW, Rosen RL, Gareen IF, Kircher SM, Herman BA, Carlos RC, Kumar S, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany C, Shanafelt TD, Wagner LI, Land SR, Park ER, Ostroff JS. Cigarette and Alternative Tobacco Product Use among Adult Cancer Survivors Enrolled in 9 ECOG-ACRIN Clinical Trials. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 Nov 1;32(11):1552-1557. PMID: 37410096
- Walter AW, Lee JW, Streck JM, Gareen IF, Herman BA, Kircher SM, Carlos RC, Kumar SK, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany-Afdhal CM, Shanafelt TD, Wagner LI, Land SR, Ostroff JS, Park ER. The effect of neighborhood socioeconomic disadvantage on smoking status, quit attempts, and receipt of cessation support among adults with cancer: Results from nine ECOG-ACRIN Cancer Research Group trials. Cancer. 2024 Feb 1;130(3):439-452. Epub 2023 Oct 5. PMID: 37795845
- Ritchie EK, Klepin HD, Storrick E, Major B, Le-Rademacher J, Wadleigh M, Walker A, Larson RA, Roboz GJ. Geriatric assessment for older adults receiving less-intensive therapy for acute myeloid leukemia: report of CALGB 361101. Blood advances. 2022 Jun 28;6(12):3812-3820. PMID: 35420672