Principal Investigator

Raymond U
Osarogiagbon
Awardee Organization

Baptist Memorial Hospital - Tipton
United States

Fiscal Year
2024
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Baptist Memorial Health Care/Mid South NCORP Minority Underserved Consortium

The Baptist Memorial Health Care/Mid-South Minority Underserved NCORP is part of Baptist Memorial Healthcare Corporation (BMHCC), a non-for-profit faith-based healthcare system with 22 hospitals, 21 outpatient oncology clinics, 8 radiation facilities, and 19 outpatient infusion centers, providing care for approximately 8000 new cancer patients each year. BMHCC’s service area covers 111 counties, 4.3 million people. This is 44% of the 252 counties and parishes in the Delta Regional Authority, congressionally acknowledged as the most indigent population in the US. BMHCC provides 25% of cancer care in this racially, socioeconomically and culturally diverse region, which has some of the highest volumes of cancer and the most fragile public health infrastructure in the US. Before our NCORP, these patients had no access to clinical trials. In the 4 years since our NCORP began in August 2014, more than 90 patients per year have been enrolled into trials, including 168 patients in 2017/18; 39% of our enrolled patients are racial minorities, 17% reside in rural areas, 13% are uninsured, 21% have Medicaid. Members of our NCORP serve on multiple NCORP taskforces and NCI Steering Committees, including the Cancer Prevention Steering Committee. We have used our unique expertise in establishing Multidisciplinary Care Delivery programs in Breast, Thoracic, Gastrointestinal and Hematologic Oncology to develop Disease-Specific Research Groups that link our NCORP research closely to our clinical oncology care programs. This strategy has accelerated our progress in the past 2 years. Our system-wide implementation of the Electronic Health Record system, EPIC, has enhanced our research ability, especially in Cancer Care Delivery Research. For the new funding cycle, we propose to expand our NCORP research infrastructure across the full extent of BMHCC, with special emphasis on increasing patient recruitment across the state of Mississippi. Using Implementation and Team Science principles and a data-driven approach, our overarching goal is to increase the proportion of BMHCC oncology patients who participate in clinical trials from <3% in 2018 to 10% by 2025. With almost 8000 annual new cancer cases, this would significantly exceed the minimum requirements of the NCORP, to the benefit of our patients, communities and healthcare system, because we believe that ‘the best treatment is a clinical trial.’ Our specific aims are to increase the: 1.) number of active sites from 5 to 16 by 2025, by expanding to all our Mississippi institutions; 2.) proportion of oncology-related providers accruing patients to >90%; 3.) clinical trials activity in urogenital and gynecologic oncology; 4.) average annual patient-enrollment into NCORP trials from 90 to >250. Achieving our goal will help achieve the NCI’s mission of improving the health of this key US population demographic by narrowing a major recognized health disparity: poor access of the large indigent, racial minority and rural populations within the Mississippi Delta region to high quality oncologic care.

Publications

  • Borghaei H, Redman MW, Kelly K, Waqar SN, Robert F, Kiefer GJ, Stella PJ, Minichiello K, Gandara DR, Herbst RS, Papadimitrakopoulou VA. SWOG S1400A (NCT02154490): A Phase II Study of Durvalumab for Patients With Previously Treated Stage IV or Recurrent Squamous Cell Lung Cancer (Lung-MAP Sub-study). Clinical lung cancer. 2021 May;22(3):178-186. Epub 2020 Nov 10. PMID: 33358401
  • Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS. Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406). Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021 Feb 1;39(4):285-294. Epub 2020 Dec 23. PMID: 33356422
  • Henry NL, Unger JM, Schott AF, Fehrenbacher L, Flynn PJ, Prow DM, Sharer CW, Burton GV, Kuzma CS, Moseley A, Lew DL, Fisch MJ, Moinpour CM, Hershman DL, Wade JL 3rd. Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Feb 1;36(4):326-332. Epub 2017 Nov 14. PMID: 29136387
  • Persky DO, Li H, Rimsza LM, Barr PM, Popplewell LL, Bane CL, Von Gehr A, LeBlanc M, Fisher RI, Smith SM, Friedberg JW. A phase I/II trial of vorinostat (SAHA) in combination with rituximab-CHOP in patients with newly diagnosed advanced stage diffuse large B-cell lymphoma (DLBCL): SWOG S0806. American journal of hematology. 2018 Aug;93(4):486-493. Epub 2018 Jan 25. PMID: 29266344
  • Ahmad SA, Duong M, Sohal DPS, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS. Surgical Outcome Results From SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcinoma. Annals of surgery. 2020 Sep 1;272(3):481-486. PMID: 32740235
  • Goldberg SB, Redman MW, Lilenbaum R, Politi K, Stinchcombe TE, Horn L, Chen EH, Mashru SH, Gettinger SN, Melnick MA, Herbst RS, Baumgart MA, Miao J, Moon J, Kelly K, Gandara DR. Randomized Trial of Afatinib Plus Cetuximab Versus Afatinib Alone for First-Line Treatment of EGFR-Mutant Non-Small-Cell Lung Cancer: Final Results From SWOG S1403. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2020 Dec 1;38(34):4076-4085. Epub 2020 Oct 6. PMID: 33021871
  • Edelman MJ, Redman MW, Albain KS, McGary EC, Rafique NM, Petro D, Waqar SN, Minichiello K, Miao J, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS. SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Oct;14(10):1853-1859. Epub 2019 Jul 11. PMID: 31302234