Principal Investigator

Luis Javier
Santos-Reyes
Awardee Organization

Comprehensive Cancer Center/ Univ/Pr
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Puerto Rico Minority Underserved NCI Community Oncology Research Program (Puerto Rico MUNCORP)

The PR NCORP will be the only organization that conducts significant, meaningful NCI - directed Clinical Cancer Research on the island of Puerto Rico focused on minorities and underserved communities for cancer treatment and cancer care delivery. It will be the backbone for the development of the multidisciplinary cancer care for the newly built University of Puerto Rico Comprehensive Cancer Center (UPRCCC), which will officially open to patient care on August 20, 2018. All faculty members including translational researchers and clinical care providers are expected to participate in the PR NCORP for the purposes of broadening the catchment base for accrual to our clinical trials. Each department within the CCCUPR, such as Gynecologic Oncology for example with four active faculty surgeons, will participate directly in NRG studies and will use the PR NCORP as the platform for development of the department. All patients seen in the CCCUPR will be consented for enrollment in the PR NCORP broadly for purposes of demographical and clinical data gathering with specialized consent for tissue donation. The PRNCORP is also a source of knowledge to the broad oncology medical community. It will serve to improve cancer treatment and care for Adult and Pediatric patients throughout its participating institutions and beyond. Our PI's and Co-PI's are experienced professionals with over 30 years of experience in Clinical Research with very strong staff and support personnel. Our fellows and attendings are active participants of Medical Schools, tumor boards, cancer seminars and are involved in yearly updates to the Medical Community, such as ASCO and ASH Review Conference Series in the island. Our research environment will improve: (1) Pathology Departments, (2) Radiology Imaging Departments, (3) Radiotherapy Service, (4) Gastroenterology, (5) Surgery, (6) Hematology-Oncology Treatment Program and (7) Direct Patient Care.

Publications

  • Nixon AB, Sibley AB, Liu Y, Hatch AJ, Jiang C, Mulkey F, Starr MD, Brady JC, Niedzwiecki D, Venook AP, Baez-Diaz L, Lenz HJ, O'Neil BH, Innocenti F, Meyerhardt JA, O'Reilly EM, Owzar K, Hurwitz HI. Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance). Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Jul 1;28(13):2779-2788. PMID: 34965954
  • Ortiz-Ortiz KJ, Ríos-Motta R, Marín-Centeno H, Cruz-Correa MR, Ortiz AP. Emergency Presentation and Short-Term Survival Among Patients With Colorectal Cancer Enrolled in the Government Health Plan of Puerto Rico. Health services research and managerial epidemiology. 2016 May 9;3:2333392816646670. doi: 10.1177/2333392816646670. eCollection 2016 Jan-Dec. PMID: 28462276
  • Ortiz-Ortiz KJ, Ríos-Motta R, Marín-Centeno H, Cruz-Correa M, Ortiz AP. Factors associated with late stage at diagnosis among Puerto Rico's government health plan colorectal cancer patients: a cross-sectional study. BMC health services research. 2016 Aug 3;16(a):344. PMID: 27488381
  • Ortiz-Ortiz KJ, Tortolero-Luna G, Torres-Cintrón CR, Zavala-Zegarra DE, Gierbolini-Bermúdez A, Ramos-Fernández MR. High-Intensity End-of-Life Care Among Patients With GI Cancer in Puerto Rico: A Population-Based Study. JCO oncology practice. 2021 Feb;17(2):e168-e177. PMID: 33567240
  • Bhatia AK, Lee JW, Pinto HA, Jacobs CD, Limburg PJ, Rubin P, Arusell RM, Dunphy EP, Khandekar JD, Reiner SA, Baez-Diaz L, Celano P, Li S, Li Y, Burtness BA, Adams GL, Pandya KJ. Double-blind, randomized phase 3 trial of low-dose 13-cis retinoic acid in the prevention of second primaries in head and neck cancer: Long-term follow-up of a trial of the Eastern Cooperative Oncology Group-ACRIN Cancer Research Group (C0590). Cancer. 2017 Dec 1;123(23):4653-4662. Epub 2017 Aug 7. PMID: 28786105
  • Chance WW, Ortiz-Ortiz KJ, Liao KP, Zavala Zegarra DE, Stauder MC, Giordano SH, Tortolero-Luna G, Guadagnolo BA. Underuse of Radiation Therapy After Breast Conservation Surgery in Puerto Rico: A Puerto Rico Central Cancer Registry-Health Insurance Linkage Database Study. Journal of global oncology. 2018 Sep;4:1-9. Epub 2017 May 11. PMID: 30241162
  • Tortolero-Luna G, Torres-Cintrón CR, Alvarado-Ortiz M, Ortiz-Ortiz KJ, Zavala-Zegarra DE, Mora-Piñero E. Incidence of thyroid cancer in Puerto Rico and the US by racial/ethnic group, 2011-2015. BMC cancer. 2019 Jun 28;19(1):637. PMID: 31253133