Program Official
Principal Investigator
Seema
Harichand
Awardee Organization
Iowa Oncology Research Association
United States
Fiscal Year
2024
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date
NIH RePORTER
For more information, see NIH RePORTER Project 5UG1CA189816-11
Iowa-Wide Oncology Research Coalition (I-WORC)
The Iowa-Wide Oncology Research Coalition (I-WORC) is a multidisciplinary consortium of nineteen components and six sub-component performance sites comprised of twelve hospitals, including one designated children’s hospital, nine gynecologic, medical, pediatric, radiation, and surgical oncology practices and sixty-five physician investigators. In addition to the operations office in Des Moines, the I-WORC has component sites located in four geographical regions in Iowa (Ames, Cedar Rapids, Mason City and Ottumwa/Fairfield) and one geographical region in Moline, Illinois. I-WORC is an original NCI Community Oncology Research Program (NCORP) Community Site and has affiliations with the following research bases: Alliance, ECOG-ACRIN, NRG, Wake Forest, and COG. I-WORC also actively participates in other non-member research base studies through the Cancer Trials Support Unit (CTSU) and has experience using the Central Investigational Review Board (CIRB) for human subjects review. The goals of I-WORC are: 1) Provide excellence in cancer care to patients and families through participation in high quality cancer research studies including control, prevention, treatment and care delivery; 2) Support the goals and work of research bases with involvement of I-WORC investigators and research staff to provide insight into clinical significance and feasibility during concept and protocol development, as well as identification of unique patient populations; 3) Increase public and professional awareness of clinical trials through community outreach efforts and collaboration with other medical providers in the community; 4) Increase accrual in clinical studies by building on prior recruitment strategies implemented in previous cancer control/cancer prevention, precision medicine, and treatment studies; 5) Develop strategies to increase clinical trial participation in racial/ethnic minorities, adolescent and young adult (AYA) and elderly, sexual and gender minorities, and the underserved population in rural areas; 6) Collaborate with local health care institutions to increase participation in correlative and translational bio-specimen collection studies; 7) Collaborate with local health care institutions to continue to develop and expand participation in cancer care delivery studies; 8) Capture and document screening efforts for clinical trial enrollment and address cancer health disparities by building on prior screening log strategies.
Publications
- Parikh K, Mandrekar SJ, Allen-Ziegler K, Esplin B, Tan AD, Marchello B, Adjei AA, Molina JR. A Phase II Study of Pazopanib in Patients with Malignant Pleural Mesothelioma: NCCTG N0623 (Alliance). The oncologist. 2020 Jun;25(6):523-531. Epub 2019 Dec 24. PMID: 31872928
- Henry NL, Unger JM, Schott AF, Fehrenbacher L, Flynn PJ, Prow DM, Sharer CW, Burton GV, Kuzma CS, Moseley A, Lew DL, Fisch MJ, Moinpour CM, Hershman DL, Wade JL 3rd. Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Feb 1;36(4):326-332. Epub 2017 Nov 14. PMID: 29136387
- Halfdanarson TR, Foster NR, Kim GP, Meyers JP, Smyrk TC, McCullough AE, Ames MM, Jaffe JP, Alberts SR. A Phase II Randomized Trial of Panitumumab, Erlotinib, and Gemcitabine Versus Erlotinib and Gemcitabine in Patients with Untreated, Metastatic Pancreatic Adenocarcinoma: North Central Cancer Treatment Group Trial N064B (Alliance). The oncologist. 2019 May;24(5):589-e160. Epub 2019 Jan 24. PMID: 30679315
- Galanis E, Anderson SK, Twohy EL, Carrero XW, Dixon JG, Tran DD, Jeyapalan SA, Anderson DM, Kaufmann TJ, Feathers RW, Giannini C, Buckner JC, Anastasiadis PZ, Schiff D. A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872. Cancer. 2019 Nov 1;125(21):3790-3800. Epub 2019 Jul 10. PMID: 31290996
- Barton DL, Atherton PJ, Satele DV, Qin R, Dakhil S, Pipe T, Hobday T, Fee-Schroeder K, Loprinzi CL. A randomized phase II trial evaluating two non-pharmacologic interventions in cancer survivors for the treatment of sleep-wake disturbances: NCCTG N07C4 (Alliance). Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2020 Dec;28(12):6085-6094. Epub 2020 Apr 19. PMID: 32307658
- Halfdanarson TR, Foster NR, Kim GP, Haddock MG, Dakhil SR, Behrens RJ, Alberts SR. N064A (Alliance): Phase II Study of Panitumumab, Chemotherapy, and External Beam Radiation in Patients with Locally Advanced Pancreatic Adenocarcinoma. The oncologist. 2022 Jul 5;27(7):534-e546. PMID: 35285484
- Bradbury AR, Lee JW, Gaieski JB, Li S, Gareen IF, Flaherty KT, Herman BA, Domchek SM, DeMichele AM, Maxwell KN, Onitilo AA, Virani S, Park S, Faller BA, Grant SC, Ramaekers RC, Behrens RJ, Nambudiri GS, Carlos RC, Wagner LI. A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152). Cancer. 2022 Apr 1;128(7):1381-1391. Epub 2021 Dec 10. PMID: 34890045
- Conti RM, McCue S, Dockter T, Gunn HJ, Dusetzina SB, Bennett AV, Rapkin B, Gracia G, Jazowski S, Johnson M, Behrens R, Richardson P, Subbiah N, Chow S, Chang GJ, Neuman HB, Weiss ES. Self-Reported Financial Difficulties Among Patients with Multiple Myeloma and Chronic Lymphocytic Leukemia Treated at U.S. Community Oncology Clinics (Alliance A231602CD). medRxiv : the preprint server for health sciences. 2024 Sep 18. PMID: 39371185