Principal Investigator

Bret E.B.
Awardee Organization

Essentia Institute Of Rural Health
United States

Fiscal Year
Activity Code
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Essentia Health Community Cancer Research Program - NCORP

The Essentia Health Community Cancer Research Program (EHCCRP) was originally funded by the National Cancer Institute in 1984 under the former name Duluth CCOP. EHCCRP brings the benefits of clinical research to patients in regions that would be without access to clinical trials due to the distance from the nearest comprehensive cancer center. With successful competitive CCOP grant renewals in 1987, 1990, 1995, 2000, 2005 and 2010, as well as a successful NCORP grant in 2014, EHCCRP has proven to be a sustainable and successful community oncology research program over the span of 34 years. Since the NCORP grant inception in 2014, the EHCCRP has continued its expansion in rural communities by adding additional affiliates and sub-affiliates. The EHCCRP catchment area now covers portions of five states (MN, WI, MI, ND, SD). This large geographic area is predominantly rural and includes a number of American Indian tribal communities. The strategy of the EHCCRP NCORP is to continue to offer patients in the region access to state-of-the-art cancer care through participation in NCI supported treatment, cancer control/prevention, screening, post treatment-surveillance, and imaging protocols. The NCORP grant will support the infrastructure and personnel necessary to fulfill our proposed research strategy in our catchment area. In addition, the EHCCRP NCORP will continue to develop a robust Cancer Care Delivery Research (CCDR) program; to participate in NCI supported CCDR protocols. The Alliance for Clinical Trials in Oncology will function as the primary research base for the EHCCRP and secondary research bases will include the NRG, ECOG-ACRIN, SWOG, and Wake Forest. The EHCCRP NCORP will continue to open trials through the Clinical Trials Support Unit of the NCI with full utilization of the central IRB. The goal of the EHCCRP is to accrue 350 patients annually to treatment, cancer control, prevention, screening, imaging and post-treatment surveillance protocols. EHCCRP CCDR infrastructure will grow over the coming NCORP grant period to support 6 open CCDR protocols annually. A robust culture of cancer care that supports multi-disciplinary treatments allows us to deliver the best possible therapy while maintaining a high level of accrual to clinical trials. .


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  • Halfdanarson TR, Foster NR, Kim GP, Haddock MG, Dakhil SR, Behrens RJ, Alberts SR. N064A (Alliance): Phase II Study of Panitumumab, Chemotherapy, and External Beam Radiation in Patients with Locally Advanced Pancreatic Adenocarcinoma. The oncologist. 2022 Jul 5;27(7):534-e546. PMID: 35285484
  • Galanis E, Anderson SK, Twohy EL, Carrero XW, Dixon JG, Tran DD, Jeyapalan SA, Anderson DM, Kaufmann TJ, Feathers RW, Giannini C, Buckner JC, Anastasiadis PZ, Schiff D. A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872. Cancer. 2019 Nov 1;125(21):3790-3800. Epub 2019 Jul 10. PMID: 31290996
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  • Edelman MJ, Redman MW, Albain KS, McGary EC, Rafique NM, Petro D, Waqar SN, Minichiello K, Miao J, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS. SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Oct;14(10):1853-1859. Epub 2019 Jul 11. PMID: 31302234
  • Leon-Ferre RA, Perez EA, Hillman DW, Bueno C, Perez AT, Chen B, Jenkins RB, Northfelt DW, Johnson DB, Carolla RL, Zon RT, Moreno-Aspitia A. N083E (Alliance): long-term outcomes of patients treated in a pilot phase II study of docetaxel, carboplatin, trastuzumab, and lapatinib as adjuvant therapy for early-stage HER2-positive breast cancer. Breast cancer research and treatment. 2020 Aug;182(3):613-622. Epub 2020 Jun 5. PMID: 32504284
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