Program Official

Principal Investigator

Michael G.
Goggins
Awardee Organization

Johns Hopkins University
United States

Fiscal Year
2024
Activity Code
U01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Using markers to improve pancreatic cancer screening and surveillance: a multi-center study

Patients diagnosed with Stage I pancreatic cancer have a much better outcome than most patients who present with advanced disease. The Cancer of the Pancreas Screening (CAPS) study currently follows a familial/genetic “high-risk” cohort of ~1500 patients undergo regular pancreatic surveillance. Recent results from the CAPS program indicate that most patients who maintain regular surveillance are down-staged, many are diagnosed with Stage I pancreatic cancer and achieve long-term survival. Circulating tumor marker tests are not currently used for pancreas surveillance, but we propose to evaluate blood tests for patients undergoing pancreatic surveillance. We will evaluate the use of tumor marker gene tests to better define an individual’s tumor marker normal reference range. We will evaluate the use of plasma MR spectroscopy as a diagnostic test that utilizes artificial-intelligence methods to detect subtle circulating metabolic changes associated with having pancreatic cancer. We will also determine if blood biomarker changes occur before the diagnosis of pancreatic cancer in our cohort. The addition of annual blood tests to pancreatic surveillance is expected to improve the detection of early-stage pancreatic cancer. We will continue to evaluate the long-term outcomes of patients in our cohort and bank biospecimens for future biomarker studies.
  • Douville C, Cohen JD, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Schoen RE, Tie J, Gibbs P, Goggins M, Wolfgang CL, Wang TL, Shih IM, Karchin R, Lennon AM, Hruban RH, Tomasetti C, Bettegowda C, Kinzler KW, Papadopoulos N, Vogelstein B. Assessing aneuploidy with repetitive element sequencing. Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 3;117(9):4858-4863. Epub 2020 Feb 19. PMID: 32075918
  • Smith LM, Mahoney DW, Bamlet WR, Yu F, Liu S, Goggins MG, Darabi S, Majumder S, Wang QL, Coté GA, Demeure MJ, Zhang Z, Srivastava S, Chawla A, Izmirlian G, Olson JE, Wolpin BM, Genkinger JM, Zaret KS, Brand R, Koay EJ, Oberg AL. Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2024 Dec;24(8):1265-1279. Epub 2024 Oct 29. PMID: 39516175