Program Official

Principal Investigator

Andrew T
Chan
Awardee Organization

Massachusetts General Hospital
United States

Fiscal Year
2023
Activity Code
R35
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Precision Prevention Research Program

As an internationally recognized physician-investigator, I have dedicated my career to the prevention of colorectal cancer (CRC). My most substantial contributions have influenced the evidence base supporting aspirin’s effectiveness in reducing the risk of CRC and uncovered key molecular mechanisms underlying its anticancer activity. This work has helped advance the field to a first-if-its-kind milestone recommendation for population use of aspirin for cancer prevention by the US Preventive Services Task Force. However, growing data demonstrates that the effect of aspirin may differ according to host factors, including the gut microbiome and age, suggesting that a “one-size-fits-all” approach to aspirin chemoprevention is limited. Thus, developing novel approaches to prevention through molecular risk stratification is a high priority. Building on my expertise in molecular epidemiology, clinical trials, the gut microbiome, and clinical cancer prevention, my research vision is to develop a comprehensive Precision Prevention Research Program (PPRP) through this NCI Outstanding Investigator Award. The overarching goal of this PPRP is to leverage complementary sources of human data, including population-based studies, clinical cohorts, and “living biobanks” to study the entire continuum from healthy individuals to advanced cancer patients and with resolution from single cells to large populations to acquire a more complete, multifaceted view of how interventions can be tailored to prevent cancer. Our PPRP facilitates mechanistic discovery in population studies that can lead to rapid testing of novel, molecularly-inspired biomarkers in clinical cohorts, creating opportunity for “living biobanks” for rigorous validation and advanced mechanistic investigation. Moreover, this model is reciprocal. Our clinical cohorts and translational tools using patient-derived experimental systems may also identify novel mechanisms that can be examined within the context of our population studies to confirm their relevance to cancer and improve generalizability. Through this R35, I will develop and expand this PPRP through expansion of my work in aspirin chemoprevention. Aspirin is an exemplar agent to develop this platform since efficacy for CRC prevention has already been established and its association with adverse effects, such as bleeding, necessitate a tailored approach. As the Lancet Oncology Commission report concluded: “Perhaps the most promising precision-based approach to cancer prevention in the near future involves molecular selection for repurposed low-dose aspirin” and “in view of aspirin’s potential adverse effects (e.g., bleeding), tailoring aspirin use is a high priority”. By enhancing understanding of aspirin’s mode of action, this proposal may lead to novel mechanistic biomarkers or complementary preventative interventions that may maximize the benefits of aspirin while minimizing the harms. Over the long-term, I envision that this work will provide proof-of-concept for expansion of the PPRP program as a cost-efficient platform within which to move additional cancer preventive interventions rapidly into the clinic.

Publications

  • Yang K, Forman MR, Graham BH, Monahan PO, Giovannucci EL, De Vivo I, Chan AT, Nan H. Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients. Cancer epidemiology. 2020 Oct;68:101778. Epub 2020 Jul 14. PMID: 32674053
  • Mehta RS, Mayers JR, Zhang Y, Bhosle A, Glasser NR, Nguyen LH, Ma W, Bae S, Branck T, Song K, Sebastian L, Pacheco JA, Seo HS, Clish C, Dhe-Paganon S, Ananthakrishnan AN, Franzosa EA, Balskus EP, Chan AT, Huttenhower C. Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nature medicine. 2023 Mar;29(3):700-709. Epub 2023 Feb 23. PMID: 36823301
  • Wang K, Ma W, Wu K, Ogino S, Giovannucci EL, Chan AT, Song M. Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals' Risk Profiles. Journal of the National Cancer Institute. 2021 Sep 4;113(9):1177-1185. PMID: 33734405
  • Joh HK, Lee DH, Hur J, Nimptsch K, Chang Y, Joung H, Zhang X, Rezende LFM, Lee JE, Ng K, Yuan C, Tabung FK, Meyerhardt JA, Chan AT, Pischon T, Song M, Fuchs CS, Willett WC, Cao Y, Ogino S, Giovannucci E, Wu K. Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors. Gastroenterology. 2021 Jul;161(1):128-142.e20. Epub 2021 Mar 19. PMID: 33753105
  • Knudsen MD, Wang L, Wang K, Wu K, Ogino S, Chan AT, Giovannucci E, Song M. Changes in Lifestyle Factors After Endoscopic Screening: A Prospective Study in the United States. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Jun;20(6):e1240-e1249. Epub 2021 Jul 10. PMID: 34256146
  • Zheng X, Hur J, Nguyen LH, Liu J, Song M, Wu K, Smith-Warner SA, Ogino S, Willett WC, Chan AT, Giovannucci E, Cao Y. Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. Journal of the National Cancer Institute. 2021 May 4;113(5):543-552. PMID: 33136160
  • Hur J, Otegbeye E, Joh HK, Nimptsch K, Ng K, Ogino S, Meyerhardt JA, Chan AT, Willett WC, Wu K, Giovannucci E, Cao Y. Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. Gut. 2021 Dec;70(12):2330-2336. Epub 2021 May 6. PMID: 33958435
  • Kim MN, Lo CH, Corey KE, Liu PH, Ma W, Zhang X, Jovani M, Song M, Chan AT, Simon TG. Weight gain during early adulthood, trajectory of body shape and the risk of nonalcoholic fatty liver disease: A prospective cohort study among women. Metabolism: clinical and experimental. 2020 Dec;113:154398. Epub 2020 Oct 12. PMID: 33058854
  • Yuan C, Joh HK, Wang QL, Zhang Y, Smith-Warner SA, Wang M, Song M, Cao Y, Zhang X, Zoltick ES, Hur J, Chan AT, Meyerhardt JA, Ogino S, Ng K, Giovannucci EL, Wu K. Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite. The American journal of clinical nutrition. 2022 Jun 7;115(6):1481-1489. PMID: 35470384
  • Borozan I, Zaidi SH, Harrison TA, Phipps AI, Zheng J, Lee S, Trinh QM, Steinfelder RS, Adams J, Banbury BL, Berndt SI, Brezina S, Buchanan DD, Bullman S, Cao Y, Farris AB 3rd, Figueiredo JC, Giannakis M, Heisler LE, Hopper JL, Lin Y, Luo X, Nishihara R, Mardis ER, Papadopoulos N, Qu C, Reid EEG, Thibodeau SN, Harlid S, Um CY, Hsu L, Gsur A, Campbell PT, Gallinger S, Newcomb PA, Ogino S, Sun W, Hudson TJ, Ferretti V, Peters U. Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Jan;31(1):210-220. Epub 2021 Nov 4. PMID: 34737207
  • Lo CH, Ni P, Yan Y, Ma W, Joshi AD, Nguyen LH, Mehta RS, Lochhead P, Song M, Curhan GC, Cao Y, Chan AT. Association of Proton Pump Inhibitor Use With All-Cause and Cause-Specific Mortality. Gastroenterology. 2022 Oct;163(4):852-861.e2. Epub 2022 Jul 1. PMID: 35788344
  • Cao Y, Nguyen LH, Tica S, Otegbeye E, Zong X, Roelstraete B, Chan AT, Warner BB, Stephansson O, Ludvigsson JF. Evaluation of Birth by Cesarean Delivery and Development of Early-Onset Colorectal Cancer. JAMA network open. 2023 Apr 3;6(4):e2310316. PMID: 37103933
  • Zhang Y, Wu K, Chan AT, Meyerhardt JA, Giovannucci EL. Long-Term Statin Use, Total Cholesterol Level, and Risk of Colorectal Cancer: A Prospective Cohort Study. The American journal of gastroenterology. 2022 Jan 1;117(1):158-166. PMID: 34730560
  • Ugai T, Haruki K, Väyrynen JP, Borowsky J, Fujiyoshi K, Lau MC, Akimoto N, Zhong R, Kishikawa J, Arima K, Shi SS, Zhao M, Fuchs CS, Zhang X, Giannakis M, Song M, Nan H, Meyerhardt JA, Wang M, Nowak JA, Ogino S. Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates. Mayo Clinic proceedings. 2022 Jan;97(1):124-133. PMID: 34996545
  • Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma W, Wang DD, Thompson KN, Yan Y, Branck T, Wilkinson JE, Akimoto N, Zhong R, Lau MC, Mima K, Kosumi K, Morikawa T, Rimm EB, Garrett WS, Izard J, Cao Y, Song M, Huttenhower C, Ogino S, Chan AT. The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men. Clinical and translational gastroenterology. 2021 Aug 1;12(8):e00338. PMID: 34333506
  • Ma W, Wang K, Nguyen LH, Joshi A, Cao Y, Nishihara R, Wu K, Ogino S, Giovannucci EL, Song M, Chan AT. Association of Screening Lower Endoscopy With Colorectal Cancer Incidence and Mortality in Adults Older Than 75 Years. JAMA oncology. 2021 Jul 1;7(7):985-992. PMID: 34014275
  • Nguyen LH, Cao Y, Hur J, Mehta RS, Sikavi DR, Wang Y, Ma W, Wu K, Song M, Giovannucci EL, Rimm EB, Willett WC, Garrett WS, Izard J, Huttenhower C, Chan AT. The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors. Gastroenterology. 2021 Nov;161(5):1423-1432.e4. Epub 2021 Jul 14. PMID: 34273347
  • Yang K, Prescott J, Hazra A, Meyerhardt JA, Zhang X, De Vivo I, Chan AT, Du M, Giovannucci EL, Nan H. Pre-diagnostic telomere length and colorectal cancer risk. Cancer epidemiology. 2022 Apr;77:102100. Epub 2022 Jan 13. PMID: 35033923
  • Kwon S, Ma W, Drew DA, Klempner SJ, Leonardo BM, Flynn JJ, Cao Y, Giovannucci EL, Bao Y, Fuchs CS, Song M, Chan AT. Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study. Cancer prevention research (Philadelphia, Pa.). 2022 Apr 1;15(4):265-272. PMID: 34980677
  • Wills C, He Y, Summers MG, Lin Y, Phipps AI, Watts K, Law PJ, Al-Tassan NA, Maughan TS, Kaplan R, Houlston RS, Peters U, Newcomb PA, Chan AT, Buchanan DD, Gallinger S, Marchand LL, Pai RK, Shi Q, Alberts SR, Gray V, West HD, Escott-Price V, Dunlop MG, Cheadle JP. A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients. European journal of cancer (Oxford, England : 1990). 2021 Dec;159:247-258. Epub 2021 Nov 15. PMID: 34794066
  • Ugai T, Väyrynen JP, Lau MC, Borowsky J, Akimoto N, Väyrynen SA, Zhao M, Zhong R, Haruki K, Dias Costa A, Fujiyoshi K, Arima K, Wu K, Chan AT, Cao Y, Song M, Fuchs CS, Wang M, Lennerz JK, Ng K, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S. Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer immunology, immunotherapy : CII. 2022 Apr;71(4):933-942. Epub 2021 Sep 16. PMID: 34529108
  • Ugai T, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, Campbell PT, Akimoto N, Berndt S, Brenner H, Buchanan DD, Chang-Claude J, Fujiyoshi K, Gallinger SJ, Gunter MJ, Hidaka A, Hoffmeister M, Hsu L, Jenkins MA, Milne RL, Moreno V, Newcomb PA, Nishihara R, Pai RK, Sakoda LC, Slattery ML, Sun W, Amitay EL, Alwers E, Thibodeau SN, Toland AE, Van Guelpen B, Woods MO, Zaidi SH, Potter JD, Giannakis M, Song M, Nowak JA, Phipps AI, Peters U, Ogino S. Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases. The American journal of gastroenterology. 2023 Apr 1;118(4):712-726. Epub 2022 Dec 30. PMID: 36707929
  • Zhang Y, Song M, Chan AT, Meyerhardt JA, Willett WC, Giovannucci EL. Long-term use of antihypertensive medications, hypertension and colorectal cancer risk and mortality: a prospective cohort study. British journal of cancer. 2022 Nov;127(11):1974-1982. Epub 2022 Sep 22. PMID: 36138074
  • Akimoto N, Väyrynen JP, Zhao M, Ugai T, Fujiyoshi K, Borowsky J, Zhong R, Haruki K, Arima K, Lau MC, Kishikawa J, Twombly TS, Takashima Y, Song M, Zhang X, Wu K, Chan AT, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S. Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer. Frontiers in immunology. 2022 Mar 22;13:840198. doi: 10.3389/fimmu.2022.840198. eCollection 2022. PMID: 35392092
  • Zhang Y, Song M, Chan AT, Schernhammer ES, Wolpin BM, Stampfer MJ, Meyerhardt JA, Fuchs CS, Roberts SB, Willett WC, Hu FB, Giovannucci EL, Ng K. Unrestrained eating behavior and risk of digestive system cancers: a prospective cohort study. The American journal of clinical nutrition. 2021 Nov 8;114(5):1612-1624. PMID: 34293086
  • Drew DA, Schuck MM, Magicheva-Gupta MV, Stewart KO, Gilpin KK, Miller P, Parziale MP, Pond EN, Takacsi-Nagy O, Zerjav DC, Chin SM, Mackinnon Krems J, Meixell D, Joshi AD, Ma W, Colizzo FP, Carolan PJ, Nishioka NS, Staller K, Richter JM, Khalili H, Gala MK, Garber JJ, Chung DC, Yarze JC, Zukerberg L, Petrucci G, Rocca B, Patrono C, Milne GL, Wang M, Chan AT. Effect of Low-dose and Standard-dose Aspirin on PGE2 Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial. Cancer prevention research (Philadelphia, Pa.). 2020 Oct;13(10):877-888. Epub 2020 Jul 27. PMID: 32718943
  • Wang Y, Cao Y, Lebwohl B, Song M, Sun Q, Green PHR, Giovannucci EL, Willett WC, Chan AT. Gluten Intake and Risk of Digestive System Cancers in 3 Large Prospective Cohort Studies. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2022 Sep;20(9):1986-1996.e11. Epub 2021 Nov 17. PMID: 34800737
  • Everett C, Li C, Wilkinson JE, Nguyen LH, McIver LJ, Ivey K, Izard J, Palacios N, Eliassen AH, Willett WC, Ascherio A, Sun Q, Tworoger SS, Chan AT, Garrett WS, Huttenhower C, Rimm EB, Song M. Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies. Nature protocols. 2021 Jun;16(6):2724-2731. Epub 2021 Apr 21. PMID: 33883746
  • Merino J, Linenberg I, Bermingham KM, Ganesh S, Bakker E, Delahanty LM, Chan AT, Capdevila Pujol J, Wolf J, Al Khatib H, Franks PW, Spector TD, Ordovas JM, Berry SE, Valdes AM. Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition. The American journal of clinical nutrition. 2022 Jun 7;115(6):1569-1576. PMID: 35134821
  • Yang W, Sui J, Zhao L, Ma Y, Tabung FK, Simon TG, Lee DH, Zeng X, Nguyen LH, Meyerhardt JA, Chan AT, Giovannucci EL, Zhang X. Association of Inflammatory and Insulinemic Potential of Diet and Lifestyle with Risk of Hepatocellular Carcinoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Apr;30(4):789-796. Epub 2021 Jan 29. PMID: 33514605
  • Drew DA, Klempner SJ, Chan AT. Metabolomics as a Tool for Biomarker Discovery in Gastric Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Sep;30(9):1601-1603. PMID: 34475120
  • Zhang Y, Song M, Yuan C, Chan AT, Schernhammer ES, Wolpin BM, Stampfer MJ, Meyerhardt JA, Fuchs CS, Roberts SB, Rimm EB, Willett WC, Hu FB, Giovannucci EL, Ng K. Unrestrained eating behavior and risk of mortality: A prospective cohort study. Clinical nutrition (Edinburgh, Scotland). 2021 Nov;40(11):5419-5429. Epub 2021 Sep 17. PMID: 34653818
  • Devall MAM, Drew DA, Dampier CH, Plummer SJ, Eaton S, Bryant J, Díez-Obrero V, Mo J, Kedrin D, Zerjav DC, Takacsi-Nagy O, Jennelle LT, Ali MW, Yilmaz ÖH, Moreno V, Powell SM, Chan AT, Peters U, Casey G. Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids. Cancer prevention research (Philadelphia, Pa.). 2021 Dec;14(12):1089-1100. Epub 2021 Aug 13. PMID: 34389629
  • Guo CG, Ma W, Drew DA, Cao Y, Nguyen LH, Joshi AD, Ng K, Ogino S, Meyerhardt JA, Song M, Leung WK, Giovannucci EL, Chan AT. Aspirin Use and Risk of Colorectal Cancer Among Older Adults. JAMA oncology. 2021 Mar 1;7(3):428-435. PMID: 33475710
  • Väyrynen JP, Haruki K, Lau MC, Väyrynen SA, Ugai T, Akimoto N, Zhong R, Zhao M, Dias Costa A, Borowsky J, Bell P, Takashima Y, Fujiyoshi K, Arima K, Kishikawa J, Shi SS, Twombly TS, Song M, Wu K, Chan AT, Zhang X, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment. Cancer immunology research. 2022 Feb;10(2):215-227. Epub 2021 Dec 22. PMID: 34937729
  • Kim H, Lipsyc-Sharf M, Zong X, Wang X, Hur J, Song M, Wang M, Smith-Warner SA, Fuchs C, Ogino S, Wu K, Chan AT, Cao Y, Ng K, Giovannucci EL. Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors. Gastroenterology. 2021 Oct;161(4):1208-1217.e9. Epub 2021 Jul 7. PMID: 34245763
  • Bakshi A, Cao Y, Orchard SG, Carr PR, Joshi AD, Manning AK, Buchanan DD, Umar A, Winship IM, Gibbs P, Zalcberg JR, Macrae F, McNeil JJ, Lacaze P, Chan AT. Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals. Cancer prevention research (Philadelphia, Pa.). 2022 Jul 5;15(7):447-454. PMID: 35348611
  • Wang Y, Ma W, Mehta R, Nguyen LH, Song M, Drew DA, Asnicar F, Huttenhower C, Segata N, Wolf J, Spector T, Berry S, Staller K, Chan AT. Diet and gut microbial associations in irritable bowel syndrome according to disease subtype. Gut microbes. 2023 Dec;15(2):2262130. Epub 2023 Oct 2. PMID: 37786251
  • Hua X, Dai JY, Lindström S, Harrison TA, Lin Y, Alberts SR, Alwers E, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Casey G, Chang-Claude J, Gallinger S, Giles GG, Goldberg RM, Gunter MJ, Hoffmeister M, Jenkins MA, Joshi AD, Ma W, Milne RL, Murphy N, Pai RK, Sakoda LC, Schoen RE, Shi Q, Slattery ML, Song M, White E, Marchand LL, Chan AT, Peters U, Newcomb PA. Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Jul;30(7):1349-1358. Epub 2021 May 10. PMID: 33972368
  • Lyu Z, Hang D, He X, Wu K, Cao Y, Rosner B, Chan AT, Ogino S, Li N, Dai M, Giovannucci EL, Song M. Simple Prediction Model for Colorectal Serrated Polyps: Development and External Validation Study in U.S. Prospective Cohorts. Cancer prevention research (Philadelphia, Pa.). 2023 May 1;16(5):293-302. PMID: 36857746
  • Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao L, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2021 Apr;70(4):717-724. Epub 2020 Aug 3. PMID: 32747412
  • Hang D, Wang L, Fang Z, Du M, Wang K, He X, Khandpur N, Rossato SL, Wu K, Hu Z, Shen H, Ogino S, Chan AT, Giovannucci EL, Zhang FF, Song M. Ultra-processed food consumption and risk of colorectal cancer precursors: results from 3 prospective cohorts. Journal of the National Cancer Institute. 2023 Feb 8;115(2):155-164. PMID: 36477589
  • Mehta RS, Kochar BD, Kennelty K, Ernst ME, Chan AT. Emerging approaches to polypharmacy among older adults. Nature aging. 2021 Apr;1(4):347-356. Epub 2021 Mar 22. PMID: 37117591
  • Huang Y, Hua X, Labadie JD, Harrison TA, Dai JY, Lindstrom S, Lin Y, Berndt SI, Buchanan DD, Campbell PT, Casey G, Gallinger SJ, Gunter MJ, Hoffmeister M, Jenkins MA, Sakoda LC, Schoen RE, Diergaarde B, Slattery ML, White E, Giles G, Brenner H, Chang-Claude J, Joshi A, Ma W, Pai RK, Chan AT, Peters U, Newcomb PA. Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations. International journal of cancer. 2022 May 1;150(9):1447-1454. Epub 2022 Jan 13. PMID: 34888857
  • Wang T, Fu Y, Shuai M, Zheng JS, Zhu L, Chan AT, Sun Q, Hu FB, Weiss ST, Liu YY. Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments. bioRxiv : the preprint server for biology. 2024 Jan 23. PMID: 38045337
  • Wang P, Song M, Eliassen AH, Wang M, Chan AT, Meyerhardt JA, Tabung FK, Zhang X, Ugai T, Ogino S, Giovannucci EL. Identifying modifiable risk factors to prevent aggressive colorectal cancer. International journal of cancer. 2024 May 8. Epub 2024 May 8. PMID: 38716828
  • Borowsky J, Haruki K, Lau MC, Dias Costa A, Väyrynen JP, Ugai T, Arima K, da Silva A, Felt KD, Zhao M, Gurjao C, Twombly TS, Fujiyoshi K, Väyrynen SA, Hamada T, Mima K, Bullman S, Harrison TA, Phipps AI, Peters U, Ng K, Meyerhardt JA, Song M, Giovannucci EL, Wu K, Zhang X, Freeman GJ, Huttenhower C, Garrett WS, Chan AT, Leggett BA, Whitehall VLJ, Walker N, Brown I, Bettington M, Nishihara R, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S. Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 May 15;27(10):2816-2826. Epub 2021 Feb 25. PMID: 33632927
  • Ibrahim MK, Wilechansky RM, Challa PK, Zhang X, Giovannucci E, Stampfer M, Chan AT, Simon TG. The empirical dietary inflammatory pattern score and the risk of nonalcoholic fatty liver disease and cirrhosis. Hepatology communications. 2023 Sep 15;7. (10). doi: 10.1097/HC9.0000000000000263. eCollection 2023 Oct 1. PMID: 37708448
  • Jachno KM, Heritier S, Woods RL, Mahady S, Chan A, Tonkin A, Murray A, McNeil JJ, Wolfe R. Examining evidence of time-dependent treatment effects: an illustration using regression methods. Trials. 2022 Oct 6;23(1):857. PMID: 36203169
  • Long L, Yang W, Liu L, Tobias DK, Katagiri R, Wu K, Jin L, Zhang FF, Luo X, Liu X, Ogino S, Chan AT, Meyerhardt JA, Giovannucci E, Zhang X. Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis. International journal of cancer. 2021 May 15;148(10):2471-2480. Epub 2020 Dec 29. PMID: 33341092
  • Drew DA, Chan AT. Aspirin in the Prevention of Colorectal Neoplasia. Annual review of medicine. 2021 Jan 27;72:415-430. Epub 2020 Oct 9. PMID: 33035431
  • Yuan C, Wang QL, Kim H, Babic A, Zhang J, Wolpin BM, Wu K, Song M, Ogino S, Meyerhardt JA, Chan AT, Cao Y, Giovannucci EL, Ng K. Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2023 Sep 6. Epub 2023 Sep 6. PMID: 37683882
  • Joshi AD, Chan AT. Racial Differences in Epigenetic Aging of the Colon: Implications for Colorectal Cancer. Journal of the National Cancer Institute. 2021 Nov 29;113(12):1618-1619. PMID: 33377963
  • Lo CH, Kwon S, Wang L, Polychronidis G, Knudsen MD, Zhong R, Cao Y, Wu K, Ogino S, Giovannucci EL, Chan AT, Song M. Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study. Gut. 2021 Mar;70(3):620-621. Epub 2020 Jul 20. PMID: 32690603
  • Nguyen LH, Cao Y, Batyrbekova N, Roelstraete B, Ma W, Khalili H, Song M, Chan AT, Ludvigsson JF. Antibiotic Therapy and Risk of Early-Onset Colorectal Cancer: A National Case-Control Study. Clinical and translational gastroenterology. 2022 Jan 13;13(1):e00437. PMID: 35029165
  • Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT. Aspirin for Metabolic Dysfunction-Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial. JAMA. 2024 Mar 19;331(11):920-929. PMID: 38502074
  • Zoltick ES, Smith-Warner SA, Yuan C, Wang M, Fuchs CS, Meyerhardt JA, Chan AT, Ng K, Ogino S, Stampfer MJ, Giovannucci EL, Wu K. Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival. British journal of cancer. 2021 Sep;125(7):1016-1024. Epub 2021 Jul 15. PMID: 34267328
  • Hang D, Zeleznik OA, Lu J, Joshi AD, Wu K, Hu Z, Shen H, Clish CB, Liang L, Eliassen AH, Ogino S, Meyerhardt JA, Chan AT, Song M. Plasma metabolomic profiles for colorectal cancer precursors in women. European journal of epidemiology. 2022 Apr;37(4):413-422. Epub 2022 Jan 15. PMID: 35032257
  • Yang K, Cao Y, Gurjao C, Liu Y, Guo CG, Lo CH, Zong X, Drew D, Geraghty C, Prezioso E, Moore M, Williams C, Riley T, Saul M, Ogino S, Giannakis M, Bass A, Schoen RE, Chan AT. Clinical and Genomic Characterization of Interval Colorectal Cancer in 3 Prospective Cohorts. Gastroenterology. 2022 Dec;163(6):1522-1530.e5. Epub 2022 Aug 13. PMID: 35970241
  • Zhang Y, Chan AT, Meyerhardt JA, Giovannucci EL. Timing of Aspirin Use in Colorectal Cancer Chemoprevention: A Prospective Cohort Study. Journal of the National Cancer Institute. 2021 Jul 1;113(7):841-851. PMID: 33528007
  • Wang X, Su YR, Petersen PS, Bien S, Schmit SL, Drew DA, Albanes D, Berndt SI, Brenner H, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Gruber SB, Haile RW, Harrison TA, Hoffmeister M, Jacobs EJ, Jenkins MA, Joshi AD, Li L, Lin Y, Lindor NM, Marchand LL, Martin V, Milne R, Maclnnis R, Moreno V, Nan H, Newcomb PA, Potter JD, Rennert G, Rennert H, Slattery ML, Thibodeau SN, Weinstein SJ, Woods MO, Chan AT, White E, Hsu L, Peters U. Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020 Sep;29(9):1800-1808. Epub 2020 Jul 10. PMID: 32651213
  • Brennan CA, Nakatsu G, Gallini Comeau CA, Drew DA, Glickman JN, Schoen RE, Chan AT, Garrett WS. Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. mBio. 2021 Apr 6;12. (2). PMID: 33824205
  • Polychronidis G, Wang K, Lo CH, Wang L, He M, Knudsen MD, Wu K, Joshi AD, Ogino S, Giovannucci EL, Chan AT, Song M. Gallstone Disease and Risk of Conventional Adenomas and Serrated Polyps: A Prospective Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Dec;30(12):2346-2349. Epub 2021 Oct 7. PMID: 34620626
  • Bever AM, Hang D, He X, Joshi AD, Ding M, Wu K, Chan AT, Giovannucci EL, Song M. Genetic Obesity Variants and Risk of Conventional Adenomas and Serrated Polyps. Digestive diseases and sciences. 2022 Aug;67(8):4078-4085. Epub 2021 Aug 17. PMID: 34403030
  • Arima K, Zhong R, Ugai T, Zhao M, Haruki K, Akimoto N, Lau MC, Okadome K, Mehta RS, Väyrynen JP, Kishikawa J, Twombly TS, Shi S, Fujiyoshi K, Kosumi K, Ogata Y, Baba H, Wang F, Wu K, Song M, Zhang X, Fuchs CS, Sears CL, Willett WC, Giovannucci EL, Meyerhardt JA, Garrett WS, Huttenhower C, Chan AT, Nowak JA, Giannakis M, Ogino S. Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies. Gastroenterology. 2022 Oct;163(4):862-874. Epub 2022 Jun 24. PMID: 35760086
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  • Simon TG, Chan AT. Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma. Clinics in liver disease. 2020 Nov;24(4):549-576. Epub 2020 Aug 25. PMID: 33012445
  • Cao Y, Chan AT. Vitamin D and Early-Onset Colorectal Cancer-Rays of Hope? Gastroenterology. 2023 Oct;165(4):831-833. Epub 2023 Aug 6. PMID: 37544414
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  • Li Y, Wang DD, Satija A, Ivey KL, Li J, Wilkinson JE, Li R, Baden M, Chan AT, Huttenhower C, Rimm EB, Hu FB, Sun Q. Plant-Based Diet Index and Metabolic Risk in Men: Exploring the Role of the Gut Microbiome. The Journal of nutrition. 2021 Sep 4;151(9):2780-2789. PMID: 34114015
  • Miller MS, Allen PJ, Brown PH, Chan AT, Clapper ML, Dashwood RH, Demehri S, Disis ML, DuBois RN, Glynn RJ, Kensler TW, Khan SA, Johnson BD, Liby KT, Lipkin SM, Mallery SR, Meuillet EJ, Roden RBS, Schoen RE, Sharp ZD, Shirwan H, Siegfried JM, Rao CV, You M, Vilar E, Szabo E, Mohammed A. Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. Journal of cancer prevention. 2021 Mar 30;26(1):71-82. PMID: 33842408
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  • Yan MK, Orchard SG, Adler NR, Wolfe R, McLean C, Rodriguez LM, Woods RL, Gibbs P, Chan AT, Haydon A, Mar VJ. Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial. Cancer prevention research (Philadelphia, Pa.). 2022 Jun 2;15(6):365-375. PMID: 35395069

Clinical Trials

Study Name Clinical Trial ID
ASPIRED-XT: ASPirin Intervention for the REDuction of Colorectal Cancer Risk -EXTension NCT05056896