Program Official
Principal Investigator
Raymond C. Bergan
Awardee Organization
University Of Nebraska Medical Center
United States
Fiscal Year
2024
Activity Code
R01
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date
NIH RePORTER
For more information, see NIH RePORTER Project 3R01CA276846-02S1
Regulation of extracellular proteases in prostate cancer progression to a metastatic phenotype
No changes from the Parent (CA275846)
Publications
- Liu C, Samson KK, Shats O, Bergan R. Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska. Cancer medicine. 2025 Mar;14(6):e70812. PMID: 40125616
- Mukthapuram PR, Natarajan A. Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates. Molecules (Basel, Switzerland). 2024 Jul 30;29. (15). PMID: 39125017
- Eiken AP, Schmitz E, Drengler EM, Smith AL, Skupa SA, Mohan K, Rana S, Singh S, Mallareddy JR, Mathew G, Natarajan A, El-Gamal D. The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax. Hemato. 2024 Sep;5(3):321-339. Epub 2024 Aug 27. PMID: 39450301
- Schmitz E, Ridout A, Smith AL, Eiken AP, Skupa SA, Drengler EM, Singh S, Rana S, Natarajan A, El-Gamal D. Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3. Biomedicines. 2024 Dec 16;12. (12). PMID: 39767763
- Mallareddy JR, Yang L, Lin WH, Feathers R, Ayers-Ringler J, Tolosa E, Kizhake AG, Kizhake S, Kubica SP, Boghean L, Alvarez S, Naldrett MJ, Singh S, Rana S, Zahid M, Schaefer-Klein J, Roden A, Kosari F, Anastasiadis PZ, Borad M, Natarajan A, Mansfield AS. Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders. RSC advances. 2025 Apr 3;15(13):10419-10425. doi: 10.1039/d5ra01441g. eCollection 2025 Mar 28. PMID: 40182503