Principal Investigator

Roderick H
Awardee Organization

Texas A&M University Health Science Ctr
United States

Fiscal Year
Activity Code
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

CCAR2 as a Target for Prevention of Colorectal Cancer.

Cell Cycle and Apoptosis Regulator Protein 2 (CCAR2) is overexpressed in human colorectal cancer and is associated with poor prognosis, due in part to its role as a coactivator of -catenin-dependent transcription. The dietary preventive agent sulforaphane (SFN) targets CCAR2 interacting protein histone deacetylase 3 (HDAC3) for inhibition, resulting in acetylation of CCAR2, reduced CCAR2/-catenin nuclear interactions, and attenuated -catenin-dependent transcription. The novel CCAR2 acetylation sites align with a domain linked to S1 RNA binding, providing a new mechanistic link to alternative RNA splicing by SFN and other dietary isothiocyanates (ITCs). Using novel protein domain arrays, bromodomain-containing proteins were identified that recognized acetylated forms of CCAR2. These acetyl “readers” also were inhibited by JQ1, which binds to bromodomain and extraterminal (BET) family proteins, and synergized with SFN to inhibit cell viability in colon cancer cells. CENTRAL HYPOTHESIS: In the prevention of colon cancer by dietary ITCs and mechanisticallyprioritized drug combinations, HDAC3 inhibition leads to acetylation of CCAR2 and changes in protein-protein interactions that enhance apoptosis via the inhibition of -catenin-dependent transcription and via altered RNA splicing. Aim 1a: Test the hypothesis that by inhibiting HDAC3, ITCs alter the acetylation status of CCAR2 in colon cancer cells, with consequences for -catenin signaling and apoptosis induction. Aim 1b: Perform mechanistic studies on the acetyl readers of CCAR2, and test inhibitors of readers that synergize with SFN. Aim 1c: Examine the role of CCAR2 and the DBIRD complex in RNA splicing. Aim 2a: Using the polyposis in rat colon (Pirc) model, extend to working hypothesis in vivo linking HDAC3 inhibition, CCAR2 acetylation, reduced -catenin signaling and apoptosis induction. Single acute doses of SFN, 6-SFN and 9-SFN will be tested alone and in combination with JQ1. The most effective agents from Aim 2a will be assessed for tumor suppression in the Pirc model via primary (Aim 2b) and secondary prevention protocols (Aim 2c). Using sequential endoscopy and polyp resection in live rats, define the precise timing of HDAC3 protein loss, CCAR2 acetylation, reduced nuclear CCAR2/-catenin interactions, and the downregulation of -catenin targets. Aim 2d: Extend mechanistic studies from Aim 1c linking CCAR2 acetylation to alternative RNA splicing after ITC treatment into the Pirc model. Aim 3a: In biopsies from FAP patients, establish the translational relevance of findings in the Pirc model with respect to CCAR2 overexpression and its interactions with -catenin, HDAC3, and ZIRD. Aim 3b: In colonoids from Pirc and FAP patients, test the hypothesis that SFN, 6-SFN and 9-SFN alter the acetylation status of CCAR2 and its protein-protein interactions, with consequences for -catenin signaling and apoptosis induction. Test individual ITCs and their combinations with JQ1. Aim 3c: In nude mice transplanted with FAP patient-derived xenografts or CRISPR/Cas9-engineered CCAR2-null human colon cancer cells transfected with CCAR2 WT and acetylation mutants, examine tumor suppression by ITCs±JQ1.


  • Mohan N, Dashwood RH, Rajendran P. A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. Cancers. 2024 Mar 9;16. (6). PMID: 38539439
  • Li Q, Löhr CV, Dashwood RH. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer letters. 2009 Sep 28;283(1):36-42. Epub 2009 Apr 18. PMID: 19376641
  • Ulusan AM, Rajendran P, Dashwood WM, Yavuz OF, Kapoor S, Gustafson TA, Savage MI, Brown PH, Sei S, Mohammed A, Vilar E, Dashwood RH. Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP). Cancer prevention research (Philadelphia, Pa.). 2021 Mar;14(3):325-336. Epub 2020 Dec 4. PMID: 33277315
  • Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane. Cancer letters. 2008 Oct 8;269(2):291-304. Epub 2008 May 27. PMID: 18504070
  • Johnson GS, Rajendran P, Dashwood RH. CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer science. 2020 Oct;111(10):3416-3425. Epub 2020 Aug 9. PMID: 33403784
  • Ho E, Dashwood RH. Dietary manipulation of histone structure and function. Journal of nutrigenetics and nutrigenomics. 2010;3(4-6):231-8. Epub 2011 Apr 6. PMID: 21474954
  • Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH. HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell death & disease. 2014 Oct 16;5(10):e1476. PMID: 25321483
  • Li Q, Luo C, Löhr CV, Dashwood RH. Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver. Hepatology research : the official journal of the Japan Society of Hepatology. 2011 Aug;41(8):776-83. Epub 2011 Jun 17. PMID: 21682828
  • Wang R, Dashwood RH. Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacological research. 2011 Jun;63(6):519-24. Epub 2011 Jan 18. PMID: 21251982
  • Reddy DS, Wu X, Golub VM, Dashwood WM, Dashwood RH. Measuring Histone Deacetylase Inhibition in the Brain. Current protocols in pharmacology. 2018 Jun;81(1):e41. Epub 2018 Jun 7. PMID: 29927058
  • Yun C, Dashwood WM, Kwong LN, Gao S, Yin T, Ling Q, Singh R, Dashwood RH, Hu M. Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2018 Jan 30;148:42-50. Epub 2017 Jul 25. PMID: 28957718
  • Nian H, Delage B, Pinto JT, Dashwood RH. Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis. 2008 Sep;29(9):1816-24. Epub 2008 Jul 14. PMID: 18628250
  • Zhang S, Kapoor S, Tripathi C, Perez JT, Mohan N, Dashwood WM, Zhang K, Rajendran P, Dashwood R. Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis. NPJ precision oncology. 2023 Feb 18;7(1):20. PMID: 36801948
  • Wang R, Dashwood WM, Löhr CV, Fischer KA, Pereira CB, Louderback M, Nakagama H, Bailey GS, Williams DE, Dashwood RH. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis. 2008 Apr;29(4):834-9. Epub 2008 Feb 17. PMID: 18283038
  • Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacological research. 2011 Nov;64(5):456-63. Epub 2011 Jul 26. PMID: 21816223
  • Ho E, Dashwood RH. Dietary manipulation of histone structure and function. World review of nutrition and dietetics. 2010;101:95-102. Epub 2010 Apr 30. PMID: 20436256
  • Nian H, Delage B, Ho E, Dashwood RH. Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environmental and molecular mutagenesis. 2009 Apr;50(3):213-21. PMID: 19197985
  • Chen YS, Wang R, Dashwood WM, Löhr CV, Williams DE, Ho E, Mertens-Talcott S, Dashwood RH. A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. Archives of toxicology. 2017 Oct;91(10):3415-3425. Epub 2017 Mar 13. PMID: 28289824
  • Bhattacharjee S, Dashwood RH. Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals. Antioxidants (Basel, Switzerland). 2020 Sep 14;9. (9). PMID: 32938017
  • Dashwood RH. Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021 Mar 6;43(1):8. PMID: 33676582
  • Kapoor S, Damiani E, Wang S, Dharmanand R, Tripathi C, Tovar Perez JE, Dashwood WM, Rajendran P, Dashwood RH. BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells. Nutrients. 2022 Oct 15;14. (20). PMID: 36297001
  • Okonkwo A, Mitra J, Johnson GS, Li L, Dashwood WM, Hegde ML, Yue C, Dashwood RH, Rajendran P. Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Molecular nutrition & food research. 2018 Sep;62(18):e1800228. Epub 2018 Jul 19. PMID: 29924908
  • Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH. A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clinical epigenetics. 2012 Sep 24;4(1):16. PMID: 23006636
  • Rajendran P, Williams DE, Ho E, Dashwood RH. Metabolism as a key to histone deacetylase inhibition. Critical reviews in biochemistry and molecular biology. 2011 Jun;46(3):181-99. Epub 2011 Apr 5. PMID: 21599534
  • Kapoor S, Gustafson T, Zhang M, Chen YS, Li J, Nguyen N, Perez JET, Dashwood WM, Rajendran P, Dashwood RH. Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells. Cancers. 2021 Mar 22;13. (6). PMID: 33809839
  • Lee SH, Richardson RL, Dashwood RH, Baek SJ. Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. The Journal of nutritional biochemistry. 2012 Jun;23(6):646-55. Epub 2011 Jul 20. PMID: 21764279
  • Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, Johnson GS, Chang JH, Löhr CV, Williams DE, Dashwood RH, Hendrix DA, Ho E. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. The Journal of nutritional biochemistry. 2017 Apr;42:72-83. Epub 2017 Jan 12. PMID: 28131897
  • Ho E, Beaver LM, Williams DE, Dashwood RH. Dietary factors and epigenetic regulation for prostate cancer prevention. Advances in nutrition (Bethesda, Md.). 2011 Nov;2(6):497-510. Epub 2011 Nov 3. PMID: 22332092
  • Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013 Jun;8(6):612-23. Epub 2013 Apr 26. PMID: 23770684
  • Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PloS one. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014. PMID: 24466240
  • Larsen CA, Dashwood RH, Bisson WH. Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. Pharmacological research. 2010 Dec;62(6):457-64. Epub 2010 Aug 4. PMID: 20691268
  • Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E, Dashwood RH. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Molecular cancer. 2011 May 30;10:68. PMID: 21624135
  • Rajendran P, Johnson G, Li L, Chen YS, Dashwood M, Nguyen N, Ulusan A, Ertem F, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HC, Lieberman D, Beaver L, Ho E, Bedford M, Chang K, Vilar E, Dashwood R. Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. Cancer research. 2019 Mar 1;79(5):918-927. Epub 2019 Jan 14. PMID: 30643017
  • Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH, Smoot D. Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Digestive diseases and sciences. 2009 Oct;54(10):2109-17. Epub 2008 Dec 5. PMID: 19057998
  • Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, Bisson WH, Dashwood RH, Pinto JT. Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer prevention research (Philadelphia, Pa.). 2009 Jul;2(7):683-93. PMID: 19584079
  • Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, Wong CP, Zhang Z, Williams DE, Dashwood RH, Shannon J, Thuillier P, Ho E. Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice. Current developments in nutrition. 2017 Dec 26;2(3):nzy002. doi: 10.1093/cdn/nzy002. eCollection 2018 Mar. PMID: 30019025
  • Chen YS, Li J, Menon R, Jayaraman A, Lee K, Huang Y, Dashwood WM, Zhang K, Sun D, Dashwood RH. Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut microbes. 2021 Jan-Dec;13(1):1972756. PMID: 34494932
  • Chen YS, Li J, Neja S, Kapoor S, Tovar Perez JE, Tripathi C, Menon R, Jayaraman A, Lee K, Dashwood WM, Wang S, Zhang K, Kobayashi K, Rajendran P, Dashwood R. Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN-γ Signaling. Cells. 2022 Feb 7;11. (3). PMID: 35159382
  • Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Molecular nutrition & food research. 2012 Aug;56(8):1259-69. Epub 2012 May 29. PMID: 22641368
  • Nian H, Bisson WH, Dashwood WM, Pinto JT, Dashwood RH. Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis. 2009 Aug;30(8):1416-23. Epub 2009 Jun 15. PMID: 19528666
  • Parasramka MA, Ho E, Williams DE, Dashwood RH. MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Molecular carcinogenesis. 2012 Mar;51(3):213-30. Epub 2011 Jul 7. PMID: 21739482
  • Paquette CE, Kent ML, Peterson TS, Wang R, Dashwood RH, Löhr CV. Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Diseases of aquatic organisms. 2015 Oct 27;116(3):191-7. PMID: 26503773
  • Chimploy K, Díaz GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, Dashwood RH. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. International journal of cancer. 2009 Nov 1;125(9):2086-94. PMID: 19585502
  • Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH. Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clinical epigenetics. 2015 Sep 18;7(1):102. doi: 10.1186/s13148-015-0132-y. eCollection 2015. PMID: 26388957
  • Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q. Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. Cellular and molecular gastroenterology and hepatology. 2018 Mar 9;6(1):65-78. doi: 10.1016/j.jcmgh.2018.02.014. eCollection 2018. PMID: 29928672
  • Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). International journal of cancer. 2011 Jun 1;128(11):2581-90. Epub 2010 Oct 8. PMID: 20715105
  • Wang R, Chen YS, Dashwood WM, Li Q, Löhr CV, Fischer K, Ho E, Williams DE, Dashwood RH. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. Molecular carcinogenesis. 2017 Jul;56(7):1733-1742. Epub 2017 Mar 6. PMID: 28218467
  • Damiani E, Duran MN, Mohan N, Rajendran P, Dashwood RH. Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception. Journal of cancer prevention. 2020 Dec 30;25(4):189-203. PMID: 33409252
  • Larsen CA, Bisson WH, Dashwood RH. Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. Journal of medicinal chemistry. 2009 Nov 12;52(21):6543-5. PMID: 19839593
  • Wang R, Dashwood WM, Löhr CV, Fischer KA, Nakagama H, Williams DE, Dashwood RH. beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. Cancer science. 2008 Sep;99(9):1754-9. Epub 2008 Jul 4. PMID: 18616682
  • Delage B, Dashwood RH. Dietary manipulation of histone structure and function. Annual review of nutrition. 2008;28:347-66. PMID: 18598138
  • Rajendran P, Ho E, Williams DE, Dashwood RH. Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical epigenetics. 2011;3(1):4. Epub 2011 Oct 26. PMID: 22247744
  • Ho E, Clarke JD, Dashwood RH. Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. The Journal of nutrition. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. PMID: 19812222
  • Johnson GS, Li J, Beaver LM, Dashwood WM, Sun D, Rajendran P, Williams DE, Ho E, Dashwood RH. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Molecular nutrition & food research. 2017 Apr;61. (4). Epub 2017 Jan 3. PMID: 27860235
  • Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E. Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharmaceutical research. 2011 Dec;28(12):3171-9. Epub 2011 Jun 17. PMID: 21681606
  • Dashwood RH, Ho E. Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutrition reviews. 2008 Aug;66 Suppl 1(Suppl 1):S36-8. PMID: 18673487
  • Beaver LM, Buchanan A, Sokolowski EI, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E. Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Molecular nutrition & food research. 2014 Oct;58(10):2001-13. Epub 2014 Aug 5. PMID: 25044704
  • Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E. 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicology and applied pharmacology. 2012 Sep 15;263(3):345-51. Epub 2012 Jul 16. PMID: 22800507
  • W Watson G, M Beaver L, E Williams D, H Dashwood R, Ho E. Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. The AAPS journal. 2013 Oct;15(4):951-61. Epub 2013 Jun 26. PMID: 23800833
  • Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. International journal of cancer. 2013 Mar 1;132(5):1004-12. Epub 2012 Aug 24. PMID: 22865632
  • Wang R, Kang Y, Löhr CV, Fischer KA, Bradford CS, Johnson G, Dashwood WM, Williams DE, Ho E, Dashwood RH. Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer. Cancer letters. 2016 Oct 28;381(2):341-8. Epub 2016 Aug 15. PMID: 27539959
  • Kim E, Bisson WH, Löhr CV, Williams DE, Ho E, Dashwood RH, Rajendran P. Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Current topics in medicinal chemistry. 2016;16(7):714-31. PMID: 26303421
  • Ertem F, Dashwood WM, Rajendran P, Raju G, Rashid A, Dashwood R. Development of a murine colonoscopic polypectomy model (with videos). Gastrointestinal endoscopy. 2016 Jun;83(6):1272-6. Epub 2015 Nov 30. PMID: 26658879
  • Neja S, Dashwood WM, Dashwood RH, Rajendran P. Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors. Nutrients. 2024 Jan 30;16. (3). PMID: 38337680