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A Randomized Trial of Bicalutamide in Non-Muscle Invasive Bladder Cancer

Major Program
Cancer Prevention Clinical Trials Network
Research Group
Prostate and Urologic Cancer
Sponsor
University of Wisconsin, Madison
Status
Recruiting
NCT ID
NCT05521698
This phase I trial evaluates the effects of bicalutamide, compared to no study drug (NSD), on epidermal growth factor receptor (EGFR) protein expression in patients with non-muscle invasive bladder cancer. Bicalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of tumor cells. Previous studies have suggested that expression of a protein called EGFR on tumor cells is related to bladder cancer disease progression. This trial may help doctors evaluate if bicalutamide has any effect on EGFR expression in patients with non-muscle invasive bladder cancer.
Intervention
Bicalutamide, Biopsy Procedure, Biospecimen Collection, Questionnaire Administration, Transurethral Resection of Bladder Tumor
Condition
Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma
Investigators
Edward M Messing, Kyle A. Richards, Michael A. Ahdoot, Juan Chipollini, Sandeep Gurram, Debasish Sundi
CT Research Area
Prevention

See list of participating sites