Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer

Research Group
Nutritional Science
University of Illinois at Chicago
Recruiting ID
For more information, see NCT04753359
A Mediterranean Diet (MedDiet), a largely plant-based dietary pattern, is relevant to CRC
prevention and microbial production of anti-cancer metabolites in observational studies. A
MedDiet can shift BA metabolism as shown in primates and when combined with calorie
restriction, shows superior adherence and weight control in humans, given its palatability.
To date, no studies have tested in an RCT the effects of a MedDiet alone (MedA), WL through
lifestyle intervention (WL-A) or a calorie-restricted MedDiet for WL (WL-Med) on the BA-gut
microbiome axis and its relevance to CRC prevention among AAs. A multidisciplinary team
combining expertise in psychology, nutrition, microbiology, molecular cell biology,
computational biology, medicine and biostatistics, proposes to conduct a four-arm RCT in
which 232 obese AAs, 45-75 years old complete one of the following 6-month interventions:
Med-A, weight stable; WL-A, calorie restriction with no diet pattern change; WLMed; or
Control. The investigators will use samples and data collected at baseline, mid-study
(month-3) and post-intervention to compare the effects of the interventions on 1)
Concentration and composition of circulating and fecal BAs; 2) Gut microbiota and metabolic
function; and 3) Gene expression profiles of exfoliated intestinal epithelial cells.
Med, WL
Colorectal Cancer, Diet Habit
Lisa Tussing-Humphreys, PhD, RD, Marian Fitzgibbon, PhD

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