Netupitant/Palonosetron Hydrochloride and Dexamethasone With or Without Prochlorperazine or Olanzapine in Improving Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer

This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and
dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron
hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in
patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may
help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.


Dexamethasone, Laboratory Biomarker Analysis, Netupitant/Palonosetron Hydrochloride, Olanzapine, Placebo, Prochlorperazine, Quality-of-Life Assessment


Breast Carcinoma


Luke Peppone, Bryan A. Faller, Brian L. Burnette

See list of participating sites