Major Program
Phase 0 I II Cancer Prevention Clinical Trials Program
Research Group
Breast and Gynecologic Cancer
Sponsor
University of Washington
Status
Active, not recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT02780401
This phase I trial studies the side effects and best dose of a vaccine therapy in preventing
cancer from coming back in patients with non-metastatic, node positive, human epidermal
growth factor receptor (HER)2 negative breast cancer in which all signs and symptoms have
disappeared. Vaccines made from deoxyribonucleic acid (DNA) may help the body build an
effective immune response to kill tumor cells. Giving multiple vaccinations may make a
stronger immune response and prevent or delay the return of cancer.
cancer from coming back in patients with non-metastatic, node positive, human epidermal
growth factor receptor (HER)2 negative breast cancer in which all signs and symptoms have
disappeared. Vaccines made from deoxyribonucleic acid (DNA) may help the body build an
effective immune response to kill tumor cells. Giving multiple vaccinations may make a
stronger immune response and prevent or delay the return of cancer.
Intervention
Laboratory Biomarker Analysis, pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine, Sargramostim
Condition
HER2/Neu Negative, No Evidence of Disease, One or More Positive Axillary Nodes, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage III Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
Investigators
Kari Wisinski