This randomized phase IIb trial studies how well alternative dosing of exemestane before
surgery works in treating in postmenopausal patients with stage 0-II estrogen positive breast
cancer. Chemoprevention is the use of drugs to keep breast cancer from forming or coming
back. The use of exemestane may treat early stage (stage 0-II) breast cancer. Comparing the
exemestane standard dose regimen versus two alternative, less frequent dose regimens may
decrease undesirable symptoms and have similar efficacy in reducing serum estradiol.
Exemestane, Laboratory Biomarker Analysis, Pharmacological Study, Quality-of-Life Assessment, Questionnaire Administration, Therapeutic Conventional Surgery, Placebo Administration
Stage 0 Breast Cancer AJCC v6 and v7, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7