Research Group
Nutritional Science
Sponsor
City of Hope Medical Center
Status
Active, not recruiting
ClinicalTrials.gov ID
For more information, see ClinicalTrials.gov NCT02295059
The study aims to determine biological changes associated with a low vs high dose of omega 3
fatty acids, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), over 12 months in women
at risk for recurrent breast cancer. The objectives of the trial are to develop mammary
epithelial, adipose tissue specific markers of exposure and response to omega 3 fatty acid
supplements that can be carried forward into definitive intervention trials of omega 3 fatty
acids for breast cancer prevention. The investigators will randomize 80 subjects with hormone
receptor negative, HER-2/neu overexpression positive or negative breast cancer to either a
high or low dose of omega 3 fatty acids. Using fine needle aspiration to procure cellular
samples of breast epithelial and adipose tissue, the investigators will determine the effects
of omega 3 fatty acids on mammary specific biomarkers of response.
fatty acids, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), over 12 months in women
at risk for recurrent breast cancer. The objectives of the trial are to develop mammary
epithelial, adipose tissue specific markers of exposure and response to omega 3 fatty acid
supplements that can be carried forward into definitive intervention trials of omega 3 fatty
acids for breast cancer prevention. The investigators will randomize 80 subjects with hormone
receptor negative, HER-2/neu overexpression positive or negative breast cancer to either a
high or low dose of omega 3 fatty acids. Using fine needle aspiration to procure cellular
samples of breast epithelial and adipose tissue, the investigators will determine the effects
of omega 3 fatty acids on mammary specific biomarkers of response.
Intervention
omega 3 fatty acids
Condition
Breast Cancer
Investigators
Lisa D Yee, MD