Nashville Early Diagnosis Lung Cancer Project

This screening study will address the lack of molecular strategies for the early detection of
lung cancer and integrate those with epidemiological and imaging strategies.

The hypothesis is that the repeated measure of biomarkers of risk obtained from the molecular
analysis of biological specimens including those from bronchoscopy (bronchial brushings and
biopsies) may contribute to the refinement of high-risk populations and allow an earlier
clinical diagnosis.

The goal of the investigators study is to provide screening for lung cancer in a high-risk
population. In this prospective cohort it will be tested whether repeated measure of
biomarkers of risk allows early detection of lung cancer.


Blood sample collection, Bronchoalveolar lavage, Bronchoscopy, Buccal epithelium collection, Computerized tomography (CT) scan of the chest, Nasal brushings, Pulmonary function tests, Questionnaire-data collection, Sputum sample, Urine sample


Lung Cancer


Eric Grogan, MD

See list of participating sites