This screening study will address the lack of molecular strategies for the early detection of
lung cancer and integrate those with epidemiological and imaging strategies.
The hypothesis is that the repeated measure of biomarkers of risk obtained from the molecular
analysis of biological specimens including those from bronchoscopy (bronchial brushings and
biopsies) may contribute to the refinement of high-risk populations and allow an earlier
The goal of the investigators study is to provide screening for lung cancer in a high-risk
population. In this prospective cohort it will be tested whether repeated measure of
biomarkers of risk allows early detection of lung cancer.