Studying samples of blood, urine, and tissue from patients with cancer in the laboratory may
help doctors learn more about changes that may occur in DNA and identify biomarkers related
to cancer. It may also help doctors learn how genistein or placebo works in patients with
bladder cancer. This randomized phase II trial is studying genistein or placebo to compare
how they work in patients who are undergoing surgery for bladder cancer.
Recurrent Bladder Carcinoma, Stage I Bladder Cancer AJCC v6 and v7, Stage II Bladder Cancer AJCC v6 and v7, Stage III Bladder Cancer AJCC v6 and v7