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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Johnson, Constance Margaret

University Of Texas Hlth Sci Ctr Houston
United States

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy 3R01CA245054-05S1 Rachel Altshuler, Ph.D.
Johnson, Constance Margaret

University Of Texas Hlth Sci Ctr Houston
United States

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy 3R01CA245054-05S1 Rachel Altshuler, Ph.D.
Johnson, Constance Margaret

University Of Texas Hlth Sci Ctr Houston
United States

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy 3R01CA245054-05S1 Rachel Altshuler, Ph.D.
Johnson, Jeremy James

University Of Illinois At Chicago
United States

Defining the role of isoprenylated xanthones from the mangosteen for enhancing degradation of full length and variant forms of androgen receptor in prostate cancer 5R37CA227101-07 Amit Kumar, Ph.D.
Judge, Andrew Robert

University Of Florida
United States

The Complement System and Cancer Cachexia 5R01AR081648-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Judge, Andrew Robert

University Of Florida
United States

The Complement System and Cancer Cachexia 5R01AR081648-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Justilien, Verline

Mayo Clinic Jacksonville
United States

ECT2 Isoform Switch in Pancreatic Cancer. 1R21CA296671-01 Matthew Young, Ph.D.
Kachnic, Lisa A.

Columbia University Health Sciences
United States

Columbia University NCI Community Oncology Research Program 3UG1CA189960-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kachnic, Lisa A.

Columbia University Health Sciences
United States

Columbia University NCI Community Oncology Research Program 3UG1CA189960-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Kahalley, Lisa Schum

Baylor College Of Medicine
United States

Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy. 3R01CA249988-05S3 Rachel Altshuler, Ph.D.
Kalpathy-Cramer, Jayashree

University Of Colorado Denver
United States

AI algorithm development for cervical cancer screening in low resource settings 1R21CA305472-01 Nicholas Hodges, Ph.D.
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554