Principal Investigator

Lisa A.
Kachnic
Awardee Organization

Columbia University Health Sciences
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Columbia University Minority/Underserved Site NCI Community Oncology Research Program

The Herbert Irving Comprehensive Cancer Center’s Minority/Underserved National Community Oncology Research Program at Columbia University Irving Medical Center (HICCC/CUIMC/MU-NCORP) has established a robust infrastructure that facilitates the identification, activation and participation in NCORP Research Base clinical trials. The overall goal of the HICCC/CUIMC/MU-NCORP is to provide the best in cancer care to the minority/undeserved population that surrounds our cancer center. The specific aims of our program are to 1) Provide and enhance access for our community of patients and healthcare providers to a portfolio of NCI Clinical Trials Network (NCTN/NCORP) trials, specifically in the four components of cancer control, cancer prevention and screening, cancer care delivery (CCD) research and cancer treatment (Phase I, II, III) as well as tissue acquisition; 2) Enhance the accrual of minority and underserved patients onto these trials by promoting the accessibility and availability of the trial portfolio and identifying and reducing accrual barriers to meet the needs of our community, 3) Lead, participate, and promote NCORP/NCTN research base studies across the cancer care continuum with a particular focus on studies that reduce healthcare disparities, and 4) Collaborate and contribute to the NCI NCORP-wide activities. Over the past four years, this strong infrastructure has led to many accomplishments. Our MU-NCORP portfolio consists of over 150 trials, and we have enrolled over 500 patients to Cancer Control and Prevention, Cancer Care Delivery and Therapeutic Trials. We have consistently exceeded the minimum 30% accrual target for minority and underserved patient populations. In addition, we have taken leadership roles within the research bases and lead many trials. By facilitating the enrollment and participation of minority and underserved cancer patients into high impactful clinical trials, we will achieve our ultimate goal of improving survival and quality of life of all individuals regardless of age, race, ethnicity, gender, sexual orientation or socioeconomic status.

Publications

  • Dickson MA, Mahoney MR, Tap WD, D'Angelo SP, Keohan ML, Van Tine BA, Agulnik M, Horvath LE, Nair JS, Schwartz GK. Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma. Annals of oncology : official journal of the European Society for Medical Oncology. 2016 Oct;27(10):1855-60. Epub 2016 Aug 8. PMID: 27502708
  • Mair MJ, Bartsch R, Le Rhun E, Berghoff AS, Brastianos PK, Cortes J, Gan HK, Lin NU, Lassman AB, Wen PY, Weller M, van den Bent M, Preusser M. Understanding the activity of antibody-drug conjugates in primary and secondary brain tumours. Nature reviews. Clinical oncology. 2023 Jun;20(6):372-389. Epub 2023 Apr 21. PMID: 37085569
  • Henry NL, Unger JM, Schott AF, Fehrenbacher L, Flynn PJ, Prow DM, Sharer CW, Burton GV, Kuzma CS, Moseley A, Lew DL, Fisch MJ, Moinpour CM, Hershman DL, Wade JL 3rd. Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Feb 1;36(4):326-332. Epub 2017 Nov 14. PMID: 29136387
  • Lassman AB, Roberts-Rapp L, Sokolova I, Song M, Pestova E, Kular R, Mullen C, Zha Z, Lu X, Gomez E, Bhathena A, Maag D, Kumthekar P, Gan HK, Scott AM, Guseva M, Holen KD, Ansell PJ, van den Bent MJ. Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jun 1;25(11):3259-3265. Epub 2019 Feb 22. PMID: 30796037
  • Temel JS, Sloan J, Zemla T, Greer JA, Jackson VA, El-Jawahri A, Kamdar M, Kamal A, Blinderman CD, Strand J, Zylla D, Daugherty C, Furqan M, Obel J, Razaq M, Roeland EJ, Loprinzi C. Multisite, Randomized Trial of Early Integrated Palliative and Oncology Care in Patients with Advanced Lung and Gastrointestinal Cancer: Alliance A221303. Journal of palliative medicine. 2020 Jul;23(7):922-929. Epub 2020 Feb 7. PMID: 32031887
  • Chiorean EG, Guthrie KA, Philip PA, Swisher EM, Jalikis F, Pishvaian MJ, Berlin J, Noel MS, Suga JM, Garrido-Laguna I, Cardin DB, Radke MR, Duong M, Bellasea S, Lowy AM, Hochster HS. Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Dec 1;27(23):6314-6322. Epub 2021 Sep 27. PMID: 34580114
  • Lassman AB, Hoang-Xuan K, Polley MC, Brandes AA, Cairncross JG, Kros JM, Ashby LS, Taphoorn MJB, Souhami L, Dinjens WNM, Laack NN, Kouwenhoven MCM, Fink KL, French PJ, Macdonald DR, Lacombe D, Won M, Gorlia T, Mehta MP, van den Bent MJ. Joint Final Report of EORTC 26951 and RTOG 9402: Phase III Trials With Procarbazine, Lomustine, and Vincristine Chemotherapy for Anaplastic Oligodendroglial Tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Aug 10;40(23):2539-2545. Epub 2022 Jun 22. PMID: 35731991
  • Lassman AB, Sepúlveda-Sánchez JM, Cloughesy TF, Gil-Gil MJ, Puduvalli VK, Raizer JJ, De Vos FYF, Wen PY, Butowski NA, Clement PMJ, Groves MD, Belda-Iniesta C, Giglio P, Soifer HS, Rowsey S, Xu C, Avogadri F, Wei G, Moran S, Roth P. Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Jun 1;28(11):2270-2277. PMID: 35344029
  • Lassman AB, Cloughesy TF. Early results from the CODEL trial for anaplastic oligodendrogliomas: is temozolomide futile? Neuro-oncology. 2021 Mar 25;23(3):347-349. PMID: 33560350
  • Schaff LR, Lassman AB. Indications for Treatment: Is Observation or Chemotherapy Alone a Reasonable Approach in the Management of Low-Grade Gliomas? Seminars in radiation oncology. 2015 Jul;25(3):203-9. Epub 2015 Feb 23. PMID: 26050591
  • Bao R, Surriga O, Olson DJ, Allred JB, Strand CA, Zha Y, Carll T, Labadie BW, Bastos BR, Butler M, Hogg D, Musi E, Ambrosini G, Munster P, Schwartz GK, Luke JJ. Transcriptional analysis of metastatic uveal melanoma survival nominates NRP1 as a therapeutic target. Melanoma research. 2021 Feb 1;31(1):27-37. PMID: 33170593
  • Barbaro M, Blinderman CD, Iwamoto FM, Kreisl TN, Welch MR, Odia Y, Donovan LE, Joanta-Gomez AE, Evans KA, Lassman AB. Causes of Death and End-of-Life Care in Patients With Intracranial High-Grade Gliomas: A Retrospective Observational Study. Neurology. 2022 Jan 18;98(3):e260-e266. Epub 2021 Nov 18. PMID: 34795049
  • Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC. Composite grading algorithm for the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Clinical trials (London, England). 2021 Feb;18(1):104-114. Epub 2020 Dec 1. PMID: 33258687
  • Lassman AB, Cloughesy TF. Biomarkers in NOA-04: another piece to the puzzle. Neuro-oncology. 2016 Nov;18(11):1467-1469. PMID: 27738177
  • Greenlee H, Lew DL, Hershman DL, Newman VA, Hansen L, Hartman SJ, Korner J, Shi Z, Sardo Molmenti CL, Sayegh A, Fehrenbacher L, Lo S, Klemp J, Rinn K, Robertson JM, Unger J, Gralow J, Albain K, Krouse R, Fabian C. Phase II Feasibility Study of a Weight Loss Intervention in Female Breast and Colorectal Cancer Survivors (SWOG S1008). Obesity (Silver Spring, Md.). 2018 Oct;26(10):1539-1549. Epub 2018 Sep 11. PMID: 30272836
  • Hillyer GC, Park YA, Rosenberg TH, Mundi P, Patel I, Bates SE. Positive attitudes toward clinical trials among military veterans leaves unanswered questions about poor trial accrual. Seminars in oncology. 2021 Apr;48(2):130-140. Epub 2021 May 3. PMID: 34088517
  • Unger JM, Hershman DL, Arnold KB, Loomba R, Chugh R, Hwang JP, O'Rourke MA, Bhadkamkar NA, Wang LX, Siegel AB, Cooley TP, Berenberg JL, Bridges BB, Ramsey SD. Stepwise development of a cancer care delivery research study to evaluate the prevalence of virus infections in cancer patients. Future oncology (London, England). 2016 May;12(10):1219-31. Epub 2016 Mar 8. PMID: 26952901
  • Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. The Lancet. Oncology. 2022 Nov;23(11):1409-1418. Epub 2022 Oct 13. PMID: 36243020
  • Lassman AB, Wen PY, van den Bent MJ, Plotkin SR, Walenkamp AME, Green AL, Li K, Walker CJ, Chang H, Tamir S, Henegar L, Shen Y, Alvarez MJ, Califano A, Landesman Y, Kauffman MG, Shacham S, Mau-Sørensen M. A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Feb 1;28(3):452-460. Epub 2021 Nov 2. PMID: 34728525
  • Vize CJ, Kim SK, Matthews T, Macsai M, Merrell R, Hsu S, Kundu MG, Yoon J, Kennedy E, Pai M, Bain E, Lassman AB, Moazami G. A Phase 3b Study for Management of Ocular Side Effects in Patients with Epidermal Growth Factor Receptor-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin. Ophthalmic research. 2023;66(1):1030-1043. Epub 2023 May 31. PMID: 37257422
  • Chung V, McDonough S, Philip PA, Cardin D, Wang-Gillam A, Hui L, Tejani MA, Seery TE, Dy IA, Al Baghdadi T, Hendifar AE, Doyle LA, Lowy AM, Guthrie KA, Blanke CD, Hochster HS. Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial. JAMA oncology. 2017 Apr 1;3(4):516-522. PMID: 27978579
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Lassman AB, van den Bent MJ, Gan HK, Reardon DA, Kumthekar P, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Walbert T, Scott AM, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Ansell PJ, Bain E, Holen KD, Maag D, Merrell R. Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial. Neuro-oncology. 2019 Jan 1;21(1):106-114. PMID: 29982805
  • Crew KD, Anderson GL, Hershman DL, Terry MB, Tehranifar P, Lew DL, Yee M, Brown EA, Kairouz SS, Kuwajerwala N, Bevers T, Doster JE, Zarwan C, Kruper L, Minasian LM, Ford L, Arun B, Neuhouser M, Goodman GE, Brown PH. Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812). Cancer prevention research (Philadelphia, Pa.). 2019 Jul;12(7):481-490. Epub 2019 May 28. PMID: 31138522
  • Reardon DA, Desjardins A, Rixe O, Cloughesy T, Alekar S, Williams JH, Li R, Taylor CT, Lassman AB. A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma. Investigational new drugs. 2020 Dec;38(6):1784-1795. Epub 2020 May 20. PMID: 32436060
  • Lassman AB, Aldape KD, Ansell PJ, Bain E, Curran WJ, Eoli M, French PJ, Kinoshita M, Looman J, Mehta M, Muragaki Y, Narita Y, Ocampo C, Roberts-Rapp L, Song M, Vogelbaum MA, Walenkamp AME, Wang TJC, Zhang P, van den Bent MJ. Epidermal growth factor receptor (EGFR) amplification rates observed in screening patients for randomized trials in glioblastoma. Journal of neuro-oncology. 2019 Aug;144(1):205-210. Epub 2019 Jul 4. PMID: 31273577
  • Iwamoto FM, Lassman AB. Factorial clinical trials: a new approach to phase II neuro-oncology studies. Neuro-oncology. 2015 Feb;17(2):174-6. Epub 2014 Dec 1. PMID: 25452393
  • Hillyer GC, Beauchemin M, Hershman DL, Kelsen M, Brogan FL, Sandoval R, Schmitt KM, Reyes A, Terry MB, Lassman AB, Schwartz GK. Discordant attitudes and beliefs about cancer clinical trial participation between physicians, research staff, and cancer patients. Clinical trials (London, England). 2020 Apr;17(2):184-194. Epub 2020 Feb 3. PMID: 32009456
  • Haggiagi A, Lassman AB. Newly diagnosed glioblastoma in the elderly: when is temozolomide alone enough? Neuro-oncology. 2020 Aug 17;22(8):1058-1059. PMID: 32479605
  • Kumthekar PU, Avram MJ, Lassman AB, Lin NU, Lee E, Grimm SA, Schwartz M, Bell Burdett KL, Lukas RV, Dixit K, Perron I, Zhang H, Gradishar WJ, Pentsova EI, Jeyapalan S, Groves MD, Melisko M, Raizer JJ. A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics. Neuro-oncology. 2023 Mar 14;25(3):557-565. PMID: 35948282
  • Hillyer GC, MacLean SA, Beauchemin M, Basch CH, Schmitt KM, Segall L, Kelsen M, Brogan FL, Schwartz GK. YouTube Videos as a Source of Information About Clinical Trials: Observational Study. JMIR cancer. 2018 Jun 26;4(1):e10060. PMID: 29945855
  • Yang W, Su M, Yu Y, Fang Q, Zhang J, Zhang J. Dysregulation of miR-637 Is Involved in the Development of Retinopathy in Hypertension Patients and Serves a Regulatory Role in Retinol Endothelial Cell Proliferation. Ophthalmic research. 2023;66(1):1-7. Epub 2021 Feb 2. PMID: 33530086
  • Wang QL, Ma C, Yuan C, Shi Q, Wolpin BM, Zhang Y, Fuchs CS, Meyer J, Zemla T, Cheng E, Kumthekar P, Guthrie KA, Couture F, Kuebler P, Kumar P, Tan B, Krishnamurthi S, Goldberg RM, Venook A, Blanke C, Shields AF, O'Reilly EM, Meyerhardt JA, Ng K. Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance). Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Jul 14;29(14):2621-2630. PMID: 37289007
  • Schöder H, Polley MC, Knopp MV, Hall N, Kostakoglu L, Zhang J, Higley HR, Kelloff G, Liu H, Zelenetz AD, Cheson BD, Wagner-Johnston N, Kahl BS, Friedberg JW, Hsi ED, Leonard JP, Schwartz LH, Wilson WH, Bartlett NL. Prognostic value of interim FDG-PET in diffuse large cell lymphoma: results from the CALGB 50303 Clinical Trial. Blood. 2020 Jun 18;135(25):2224-2234. PMID: 32232481
  • Kim RD, McDonough S, El-Khoueiry AB, Bekaii-Saab TS, Stein SM, Sahai V, Keogh GP, Kim EJ, Baron AD, Siegel AB, Barzi A, Guthrie KA, Javle M, Hochster H. Randomised phase II trial (SWOG S1310) of single agent MEK inhibitor trametinib Versus 5-fluorouracil or capecitabine in refractory advanced biliary cancer. European journal of cancer (Oxford, England : 1990). 2020 May;130:219-227. Epub 2020 Mar 29. PMID: 32234665
  • Ellingson BM, Gerstner ER, Lassman AB, Chung C, Colman H, Cole PE, Leung D, Allen JE, Ahluwalia MS, Boxerman J, Brown M, Goldin J, Nduom E, Hassan I, Gilbert MR, Mellinghoff IK, Weller M, Chang S, Arons D, Meehan C, Selig W, Tanner K, Alfred Yung WK, van den Bent M, Wen PY, Cloughesy TF. Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors. Neuro-oncology. 2022 Aug 1;24(8):1219-1229. PMID: 35380705
  • Luke JJ, Olson DJ, Allred JB, Strand CA, Bao R, Zha Y, Carll T, Labadie BW, Bastos BR, Butler MO, Hogg D, Munster PN, Schwartz GK. Randomized Phase II Trial and Tumor Mutational Spectrum Analysis from Cabozantinib versus Chemotherapy in Metastatic Uveal Melanoma (Alliance A091201). Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Feb 15;26(4):804-811. Epub 2019 Sep 26. PMID: 31558480
  • Torka P, Pederson LD, Knopp MV, Poon D, Zhang J, Kahl BS, Higley HR, Kelloff G, Friedberg JW, Schwartz LH, Wilson WH, Leonard JP, Bartlett NL, Schöder H, Ruppert AS. Is local review of positron emission tomography scans sufficient in diffuse large B-cell lymphoma clinical trials? A CALGB 50303 analysis. Cancer medicine. 2023 Apr;12(7):8211-8217. Epub 2023 Feb 17. PMID: 36799072
  • Morris MJ, Heller G, Hillman DW, Bobek O, Ryan C, Antonarakis ES, Bryce AH, Hahn O, Beltran H, Armstrong AJ, Schwartz L, Lewis LD, Beumer JH, Langevin B, McGary EC, Mehan PT, Goldkorn A, Roth BJ, Xiao H, Watt C, Taplin ME, Halabi S, Small EJ. Randomized Phase III Study of Enzalutamide Compared With Enzalutamide Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer (Alliance A031201 Trial). Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jun 20;41(18):3352-3362. Epub 2023 Mar 30. PMID: 36996380
  • Cloughesy TF, Lassman AB. NovoTTF: where to go from here? Neuro-oncology. 2017 May 1;19(5):605-608. PMID: 28453750