Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title Sort descending	Grant Number	Program Official
Cohen, Lorenzo	University Of Tx Md Anderson Can Ctr United States	Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery	5R01CA272565-03	Brennan Streck, Ph.D., RN, M.P.H.
Wang, Jing	New York University School Of Medicine United States	Optimizing the use of ketamine to reduce chronic postsurgical pain	3UH3CA261067-05S1	Brennan Streck, Ph.D., RN, M.P.H.
Mclouth, Laurie	University Of Kentucky United States	Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment	5R01CA283929-03	Brennan Streck, Ph.D., RN, M.P.H.
Winters-Stone, Kerri M	Oregon Health & Science University United States	Patterns and predictors of symptoms, falls, and functioning across treatment and recovery in patients treated with neurotoxic chemotherapy for cancer	5R01CA248059-05	Goli Samimi, Ph.D., M.P.H.
Hu, Jim	Weill Medical Coll Of Cornell Univ United States	Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)	5R01CA259173-04	Marjorie Perloff, M.D.
Shelby, Rebecca A	Duke University United States	Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis	5R01CA249959-05	Brennan Streck, Ph.D., RN, M.P.H.
Boone, Anna	University Of Missouri-Columbia United States	Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer	1R21CA286404-01A1	Marjorie Perloff, M.D.
Paus, Ralf	University Of Miami School Of Medicine United States	Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia	1R21CA277418-01A1	Rachel Altshuler, Ph.D.
Washington, Karla	Washington University United States	Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care	5R01CA258311-05	Brennan Streck, Ph.D., RN, M.P.H.
Sands, Stephen Alan	Sloan-Kettering Inst Can Research United States	Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)	5R01CA283045-02	Marjorie Perloff, M.D.
Siskind, Leah J	University Of Louisville United States	Protecting the kidney from cisplatin induced injury and progression to chronic kidney disease	1R01CA305985-01	Marjorie Perloff, M.D.
Ross, Stephen	New York University School Of Medicine United States	Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress	5R01CA268521-04	Rachel Altshuler, Ph.D.
Kelleher, Sarah	Duke University United States	Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients	5R01CA291888-02	Brennan Streck, Ph.D., RN, M.P.H.
Spiegel, Brennan	Cedars-Sinai Medical Center United States	Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes	5R01CA252211-05	Rachel Altshuler, Ph.D.
Jim, Heather S.L.	H. Lee Moffitt Cancer Ctr & Res Inst United States	Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue	5R01CA214647-05	Brandy Heckman-Stoddard, Ph.D., M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program	Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention	Alliance for Clinical Trials in Oncology	Recruiting