Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name	PI Organization	Title Sort descending	Grant Number	Program Official
Schaverien, Mark V	University Of Tx Md Anderson Can Ctr United States	Lymphedema Prevention Through Immediate Lymphatic Reconstruction	5R01CA292908-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Flory, James H	Sloan-Kettering Inst Can Research United States	Managing metabolic disruption in pancreatic cancer to prevent weight loss and improve quality of life	5R21CA277464-02	Gabriela Riscuta, M.D., CNS
Nelson, Randy J.	West Virginia University United States	Mechanism Underlying Sleep Disruption by Mammary Tumors	5R21CA276027-02	Marjorie Perloff, M.D.
Mehrara, Babak J	Sloan-Kettering Inst Can Research United States	Mechanisms of racial disparity in breast cancer-related lymphedema	5R01CA278599-04	Asad Umar, D.V.M., Ph.D.
Kanarek, Naama	Boston Children'S Hospital United States	Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF	5R01CA282477-02	John Clifford, Ph.D.
Bower, Julienne E	University Of California Los Angeles United States	Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings	5R01CA282416-02	Brennan Streck, Ph.D., RN, M.P.H.
Rini, Christine	Northwestern University At Chicago United States	Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients	5R01CA292116-02	Brennan Streck, Ph.D., RN, M.P.H.
Palesh, Oxana G	Virginia Commonwealth University United States	Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia	5R01CA239714-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Grueber, Wesley B	Columbia University Health Sciences United States	Neuron-macrophage interactions in models of chemotherapy-induced peripheral neuropathy	5R21CA274588-02	Rachel Altshuler, Ph.D.
Chan, Alexandre	University Of California-Irvine United States	Neurotrophic strategy to mitigate chemotherapy-related brain injury	5R01CA276212-03	John Clifford, Ph.D.
Kang, Dongkyun	University Of Arizona United States	Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy	1R01CA301271-01	Rachel Altshuler, Ph.D.
Afshar-Kharghan, Vahid	University Of Tx Md Anderson Can Ctr United States	Novel Biomarkers Predicting Blood Clots in Ovarian Cancer	5R01CA275762-03	Rachel Altshuler, Ph.D.
Goode, Diana J	University Of New England United States	Novel expression of MHC class II on DRG neurons and its role in promoting antinociceptive CD4+ T cells in females during chemotherapy-induced peripheral neuropathy	5R01CA267554-04	Rachel Altshuler, Ph.D.
Taratula, Oleh	Oregon State University United States	Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia	5R37CA234006-07	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Li, Feng	University Of California Los Angeles United States	Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.	5R21CA283665-02	Guillermo Marquez, Ph.D.

Clinical Trials

Title	Intervention	Sponsor	Status
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma	Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
Learning Collaborative Versus Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer and Their Caregivers	Behavioral, Psychological or Informational Intervention, Educational Intervention, Medical Examination Assessment, Quality-of-Life Assessment, Survey Administration, Telephone-Based Intervention	University of Rochester NCORP Research Base	Active, not recruiting
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia	Biospecimen Collection, Computed Tomography, Electronic Health Record Review, Medical Device Usage and Evaluation, Physical Performance Testing, Positron Emission Tomography, Survey Administration	University of Rochester	Recruiting
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors	Manual Therapy	M.D. Anderson Cancer Center	Active, not recruiting
Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer	Adaptation of IMCP for Chinese Immigrant Cancer Patients, In-depth Patient Interviews, Individual Meaning-Centered Psychotherapy for Chinese (IMCP-Ch) (For Phase 3 and Phase 4)	Memorial Sloan Kettering Cancer Center	Active, not recruiting
Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer	metformin hydrochloride, placebo	Alliance for Clinical Trials in Oncology	Active, not recruiting
Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients With Prostate Cancer	Exercise Intervention, Methylphenidate, Placebo, Quality-of-Life Assessment, Questionnaire Administration, Stretching	M.D. Anderson Cancer Center	Active, not recruiting
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study	Educational Intervention, FitBit, Goal Setting, Health Promotion and Education, Media Intervention, Telephone-Based Intervention	Children's Oncology Group	Active, not recruiting
Mobile Health for Adherence in Breast Cancer Patients	Electronic Health Record Review, Health Promotion and Education, Health Telemonitoring, Interview, Patient Navigation, Survey Administration, Text Message-Based Navigation Intervention	ECOG-ACRIN Cancer Research Group	Recruiting
Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study	Best Practice, Biospecimen Collection, Endocrine Drug Therapy, Health Education, Questionnaire Administration, Symptom Specific Assessment Tool	SWOG Cancer Research Network	Active, not recruiting