Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience.

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

No matching Funding Opportunities were found.

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Grantee Details

PI Name	PI Organization	Title	Grant Number Sort descending	Program Official
Flynn, Kathryn E	Medical College Of Wisconsin United States	Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM)	5R01CA285925-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Xu, Xiangxi Mike	University Of Miami School Of Medicine United States	Countering microtubule stabilization within hair follicles in ovarian cancer chemotherapy	5R01CA286527-02	Rachel Altshuler, Ph.D.
Elswick, Ronald K	Virginia Commonwealth University United States	A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer	5R01CA286799-03	Asad Umar, D.V.M., Ph.D.
Gonzalez, Brian D	H. Lee Moffitt Cancer Ctr & Res Inst United States	Impact of Targeted Therapy on Cancer-Related Cognitive Impairment	5R01CA287666-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Hui, David	University Of Tx Md Anderson Can Ctr United States	Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology	5R01CA288515-02	Brennan Streck, Ph.D., RN, M.P.H.
Mosher, Catherine E	Indiana University Indianapolis United States	Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer	5R01CA289486-02
Wright, Alexi A	Dana-Farber Cancer Inst United States	Randomized trial of REVITALIZE: A telehealth intervention to reduce fatigue interference among adults with advanced ovarian cancer on PARP inhibitors	5R01CA289547-02	Goli Samimi, Ph.D., M.P.H.
Winger, Joseph Giles	Duke University United States	Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer	5R01CA291768-02	Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah	Duke University United States	Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients	5R01CA291888-02	Brennan Streck, Ph.D., RN, M.P.H.
Rini, Christine	Northwestern University At Chicago United States	Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients	5R01CA292116-02	Brennan Streck, Ph.D., RN, M.P.H.
Marker, Ryan J	University Of Colorado Denver United States	Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation	5R01CA292482-02	Goli Samimi, Ph.D., M.P.H.
Schaverien, Mark V	University Of Tx Md Anderson Can Ctr United States	Lymphedema Prevention Through Immediate Lymphatic Reconstruction	5R01CA292908-02	Brandy Heckman-Stoddard, Ph.D., M.P.H.
Jang, Mi-Hyeon	Rutgers Biomedical And Health Sciences United States	Identification of novel biomarkers and therapeutic strategies in chemobrain.	5R01CA293210-02	John Clifford, Ph.D.
Santomasso, Bianca Denise	Sloan-Kettering Inst Can Research United States	Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy	5R01CA293922-02	Monica Epstein, B.S.N., RN, OCN
Kelleher, Sarah	Duke University United States	Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings	5R21CA273832-02	Brennan Streck, Ph.D., RN, M.P.H.

Clinical Trials

Title	Intervention	Sponsor	Status
Mosaic Trial for Stem Cell Transplant Recipients	Enhanced Usual Care (Control) Website, Intervention website	Northwestern University	Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer		Wake Forest University Health Sciences	Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer	Cognitive Assessment, Quality-of-Life Assessment	Children's Oncology Group	Active, not recruiting
New Assessment System in Measuring Symptom Distress in Cancer Patients	Interview, Quality-of-Life Assessment, Questionnaire Administration	M.D. Anderson Cancer Center	Recruiting
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	Laboratory Biomarker Analysis, Nutritional Intervention, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	SWOG Cancer Research Network	Active, not recruiting
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients	Megestrol Acetate, Olanzapine, Questionnaire Administration	Alliance for Clinical Trials in Oncology	Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment	Enhanced Usual Care, Pathways	Laurie McLouth	Recruiting
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer	Endocrine therapy interruption	ETOP IBCSG Partners Foundation	Active, not recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors	Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration	Jonsson Comprehensive Cancer Center	Recruiting
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program	Health Promotion and Education, Informational Intervention, Questionnaire Administration, Smoking Cessation Intervention	Alliance for Clinical Trials in Oncology	Recruiting