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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Salami, Simpa Samuel

University Of Michigan At Ann Arbor
United States

Defining the Biological Arc of Grade Group 1 Prostate Cancer 5R37CA283857-03 Guillermo Marquez, Ph.D.
Salipante, Stephen J

University Of Washington
United States

Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations and methylation 1R33CA302385-01 Nicholas Hodges, Ph.D.
Salkowski, Lonie

University Of Wisconsin-Madison
United States

Defining and Optimizing Critical Interpretation Skills in Screening Mammography to Improve Cancer Detection 5R37CA262110-04 Guillermo Marquez, Ph.D.
Salman, Emad

Florida Assn Of Pediatric Tumor Prog
United States

The Florida Pediatric NCORP: NCI Community Oncology Research Program. 3UG1CA189973-11S1 Vanessa A. White, M.P.H.
Salman, Emad

Florida Assn Of Pediatric Tumor Prog
United States

The Florida Pediatric NCORP: NCI Community Oncology Research Program. 3UG1CA189973-11S1 Vanessa A. White, M.P.H.
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Salvemini, Daniela

Saint Louis University
United States

Fingolimod and Ozanimod for the treatment and prevention of chemobrain 5R01CA261979-04 Rachel Altshuler, Ph.D.
Sanchez, Eduardo Vilar

University Of Tx Md Anderson Can Ctr
United States

iCAN PREVENT: MD Anderson International Cancer Prevention Clinical Trials Consortium 2UG1CA242609-07 Donald Johnsey
Sanchez, Eduardo Vilar

University Of Tx Md Anderson Can Ctr
United States

Cancer Immune-Interception for Lynch Syndrome 5R01CA257375-05 Asad Umar, D.V.M., Ph.D.
Sanchez, Eduardo Vilar

University Of Tx Md Anderson Can Ctr
United States

Cancer Immune-Interception in a Spontaneous Non-Human Primate Model of Lynch Syndrome 5R01CA260761-04 Asad Umar, D.V.M., Ph.D.
Sanda, Martin G

Emory University
United States

Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern 5U01CA113913-18 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Sanda, Martin G

Emory University
United States

Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern 5U01CA113913-18 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.
Sands, Stephen Alan

Sloan-Kettering Inst Can Research
United States

Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR) 5R01CA283045-02 Marjorie Perloff, M.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554