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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Funding Opportunities

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Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Curtis, Amarinthia E

Spartanburg Regional Medical Center
United States

Upstate Carolina Consortium - Community Oncology Research Program 3UG1CA239762-06S1 Vanessa A. White, M.P.H.
Curtius, Kathleen M.

University Of California, San Diego
United States

Multiscale modeling of spatiotemporal evolution in Barrett's esophagus 5R01CA270235-03 Asad Umar, D.V.M., Ph.D.
Czerniak, Bogdan A

University Of Tx Md Anderson Can Ctr
United States

Mechanisms of Bladder Cancer Development and Its Therapeutic Vulnerabilities to Preventive and Interventive Therapy. 1P01CA296429-01A1 Howard L. Parnes, M.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms 5R01CA272147-03 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Targeting Sphingosine-1-phosphate (S1P1) receptors for the treatment of Aromatase Inhibitors-induced Musculoskeletal Symptoms 5R01CA272147-03 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 1R21CA296516-01 Rachel Altshuler, Ph.D.
Damaj, M. Imad

Virginia Commonwealth University
United States

Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy 1R21CA296516-01 Rachel Altshuler, Ph.D.
Daniel-Macdougall, Carrie

University Of Tx Md Anderson Can Ctr
United States

Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma 5R01CA291965-02 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Dashwood, Roderick H

Texas A&M University Health Science Ctr
United States

Immunoepigenetic targeting of MHC regulators in FAP 5R01CA257559-03
Debes, Jose Daniel

University Of Minnesota
United States

Biomarkers for Early Detection of Hepatitis B-Related Hepatocellular Carcinoma in Hispanics 1R37CA297814-01 Sidney Fu, M.D.
Delaney, Joe R

Medical University Of South Carolina
United States

Biologic rationale of fallopian tube removal to prevent uterine serous carcinoma 1R21CA292343-01A1 Goli Samimi, Ph.D., M.P.H.
Demb, Joshua Brian

University Of California, San Diego
United States

Optimal early colorectal cancer screening initiation 4R00CA267181-03 Claire Zhu, Ph.D.
Demehri, Shadmehr

Massachusetts General Hospital
United States

Immunosurveillance of breast glands with oncogenic germline mutations 5UG3CA290300-02 Altaf Mohammed, Ph.D.
Deng, Jie

University Of Pennsylvania
United States

Placebo-Controlled Phase II Randomized Clinical Trial of Photobiomodulation Therapy in Head and Neck Cancer Survivors with Chronic Lymphedema 1R01CA289307-01A1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Deng, Youping

University Of Hawaii At Manoa
United States

Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms 5R01CA230514-05 Christos Patriotis, Ph.D., M.Sc.

Clinical Trials

Status
Title Sort descending Intervention Sponsor Status
Testing the Application of Mepitel Film During Radiation Therapy to Reduce Radiation Related Redness and Peeling in Breast Cancer Patients Following Mastectomy Best Practice, Quality-of-Life Assessment, Questionnaire Administration, Wound Dressing Material Alliance for Clinical Trials in Oncology Active, not recruiting
Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy Best Practice, Exercise Counseling, Exercise Intervention, Magnetic Resonance Imaging, Neuropathy Assessment, Questionnaire Administration University of Rochester NCORP Research Base Active, not recruiting
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer Carboplatin, Comprehensive Geriatric Assessment, Pembrolizumab, Pemetrexed, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy) Education control, Usual care, Yoga Dana-Farber Cancer Institute Recruiting
The MIND-BC Study: MIND Diet for Breast Cancer Cognition MIND Diet, Usual Diet H. Lee Moffitt Cancer Center and Research Institute Recruiting
The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer Promoting Resilience in Stress Management (PRISM) Dana-Farber Cancer Institute Active, not recruiting
To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration, Sinecatechins ECOG-ACRIN Cancer Research Group Recruiting
Treating Breast Cancer Patients Undergoing Trastuzumab Treatment With Carvedilol to Reduce Incidence of Heart Failure Carvedilol Mayo Clinic Active, not recruiting
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer Chemotherapy, Functional Assessment, Questionnaire Administration SWOG Cancer Research Network Active, not recruiting
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer Best Practice, Biospecimen Collection, Electronic Health Record Review, Survey Administration, Triptorelin Pamoate Children's Oncology Group Recruiting