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Supportive Care and Symptom Management

The Supportive Care and Symptom Management program supports studies on the prevention or treatment of acute and chronic symptoms and morbidities related to cancer and its treatment. This includes the impact on the quality of life of patients and their informal caregivers. The program also supports studies of patients and their caregivers at the end of life.

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About Supportive Care and Symptom Management

The program supports research in three areas: prevention or treatment of acute or chronic symptoms and morbidities related to cancer, its treatment and caregiving (symptom management research); effects on quality of life from cancer, its treatment and caregiving (quality of life research); and end-of-life psychosocial issues, caregiving and treatment strategies (end-of-life research).

Through the NCI Community Oncology Research Program (NCORP), clinical trials are underway to evaluate therapies to prevent or ameliorate a broad range of symptoms and/or toxicities associated with cancer its treatment and caregiving. Other studies funded separately are investigating a range of treatment effects on health-related quality of life and a variety of influences on the end-of-life cancer experience. 

Topic Areas include: Anorexia, Cachexia, Cardiotoxicity, Caregiver Issues, Cognitive Dysfunction, Distress/Anxiety/Depression, End of Life, Fatigue, Geriatrics, Hot Flashes, Lymphedema, Medication Adherence, Mucositis, Multiple Symptoms, Musculoskeletal Symptoms, Nausea, Neuropathy, Nutrition, Oral Complications, Other Supportive Care Issues, Pain, Palliative Care, Pediatrics/Adolescents/Young Adult, Physical Functioning, Quality of Life, Skin Toxicities, Sleep Disorders, and Urinary Complications.

Selected Topics

Resources

Funding Opportunities

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Grantee Details

PI Name PI Organization Title Grant Number Program Official
Shelby, Rebecca A

Duke University
United States

Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis 5R01CA249959-05 Brennan Streck, Ph.D., RN, M.P.H.
Huberty, Jennifer Lynne

University Of Texas Hlth Science Center
United States

Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patients 5R01CA262041-05 Marjorie Perloff, M.D.
Taratula, Oleh

Oregon State University
United States

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia 5R37CA234006-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Li, Feng

University Of California Los Angeles
United States

Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer. 5R21CA283665-02 Guillermo Marquez, Ph.D.
Hundley, William Gregory

Wake Forest University Health Sciences
United States

Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment 5R33CA226960-05 Eileen Dimond, R.N., M.S.
Cheville, Andrea Lynne

Mayo Clinic Rochester
United States

Achieving Safe, Comprehensive, Digitally-Enabled Cancer Pain managemeNT” (ASCENT) Clinical Trial 5R33CA278594-04 Brennan Streck, Ph.D., RN, M.P.H.
Nelson, Randy J.

West Virginia University
United States

Mechanism Underlying Sleep Disruption by Mammary Tumors 5R21CA276027-02 Marjorie Perloff, M.D.
Kelleher, Sarah

Duke University
United States

Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings 5R21CA273832-02 Brennan Streck, Ph.D., RN, M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wang, Jing

New York University School Of Medicine
United States

Optimizing the use of ketamine to reduce chronic postsurgical pain 3UH3CA261067-05S1 Brennan Streck, Ph.D., RN, M.P.H.
Wright, Alexi A

Dana-Farber Cancer Inst
United States

Randomized trial of REVITALIZE: A telehealth intervention to reduce fatigue interference among adults with advanced ovarian cancer on PARP inhibitors 5R01CA289547-02 Goli Samimi, Ph.D., M.P.H.
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.
John, Esther M.

Stanford University
United States

Stress, inflammation, and health-related quality of life of long-term breast cancer survivors 1R21CA290430-01 Brennan Streck, Ph.D., RN, M.P.H.
Mao, Jun J

Sloan-Kettering Inst Can Research
United States

Enhanced Pain Coping in Cancer (EPIC) 5R01CA285746-02 Rachel Altshuler, Ph.D.
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.

Clinical Trials

Status
Title Intervention Sort descending Sponsor Status
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula Biospecimen Collection, Distal Pancreatectomy, Lanreotide, Questionnaire Administration, Saline SWOG Cancer Research Network Recruiting
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors Biospecimen Collection, Fisetin, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration Jonsson Comprehensive Cancer Center Recruiting
A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients Biospecimen Collection, Letermovir Children's Oncology Group Recruiting
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride, Neurocognitive Assessment, Stereotactic Radiosurgery, Survey Administration, Whole-Brain Radiotherapy NRG Oncology Recruiting
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration ECOG-ACRIN Cancer Research Group Recruiting
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors Biospecimen Collection, Questionnaire Administration SWOG Cancer Research Network Recruiting
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT Blood Specimen Collection, Quality of Life (QOL) Questionnaires, Stool Specimen Collection University of California, San Francisco Recruiting
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer Carboplatin, Comprehensive Geriatric Assessment, Pembrolizumab, Pemetrexed, Quality-of-Life Assessment, Questionnaire Administration Alliance for Clinical Trials in Oncology Active, not recruiting
Treating Breast Cancer Patients Undergoing Trastuzumab Treatment With Carvedilol to Reduce Incidence of Heart Failure Carvedilol Mayo Clinic Active, not recruiting