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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Chak, Amitabh

Case Western Reserve University
United States

Pathways of Injury and Repair in Barrett's Carcinogenesis 5P01CA269019-03 Asad Umar, D.V.M., Ph.D.
Chan, Alexandre

University Of California-Irvine
United States

Neurotrophic strategy to mitigate chemotherapy-related brain injury 5R01CA276212-03 John Clifford, Ph.D.
Chan, Andrew T

Massachusetts General Hospital
United States

MGH- PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors 3OT2CA297680-01S1 Asad Umar, D.V.M., Ph.D.
Chan, Alexandre

University Of California-Irvine
United States

Neurotrophic strategy to mitigate chemotherapy-related brain injury 5R01CA276212-03 John Clifford, Ph.D.
Chan, Daniel Wanyui

Johns Hopkins University
United States

Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesions 5U01CA274514-03 Matthew Young, Ph.D.
Chan, Andrew T

Massachusetts General Hospital
United States

Precision Prevention Research Program 5R35CA253185-06 Asad Umar, D.V.M., Ph.D.
Chan, Daniel Wanyui

Johns Hopkins University
United States

BCC for Prostate Cancer: Discovery and Translation of Biomarkers for Clinical Unmet Needs 5U2CCA271895-03 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Chapkin, Robert Stephen

Texas A&M Agrilife Research
United States

Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling 5R01CA244359-05 Amit Kumar, Ph.D.
Chen, Ru

Baylor College Of Medicine
United States

BLOOD-BASED PROTEOMIC ASSAY FOR PANCREATIC CANCER DETECTION 4UH3CA292130-02 Claire Zhu, Ph.D.
Chen, Grace Y.

University Of Michigan At Ann Arbor
United States

Targeting cancer stem-like cells and inflammation for colon cancer chemoprevention 5R21CA273646-02
Cheville, Andrea Lynne

Mayo Clinic Rochester
United States

Achieving Safe, Comprehensive, Digitally-Enabled Cancer Pain managemeNT” (ASCENT) Clinical Trial 5R33CA278594-04 Brennan Streck, Ph.D., RN, M.P.H.
Cheville, Andrea Lynne

Mayo Clinic Rochester
United States

Achieving Safe, Comprehensive, Digitally-Enabled Cancer Pain managemeNT” (ASCENT) Clinical Trial 5R33CA278594-04 Brennan Streck, Ph.D., RN, M.P.H.
Chiang, Cheng-Ming

Ut Southwestern Medical Center
United States

Small Compound Inhibitors Targeting HPV Genome Replication 1R01CA288743-01A1
Chibwesha, Carla J

Univ Of North Carolina Chapel Hill
United States

Acceptability and feasibility of combination treatment for cervical precancer among South Africa women living with HIV 5R01CA250850-05 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Chinnaiyan, Arul M

University Of Michigan At Ann Arbor
United States

Michigan-VUMC Biomarker Characterization Center 5U2CCA271854-04 Indu Kohaar, Ph.D., M.Phil., M.Sc.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554