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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Warner, Erica T

Massachusetts General Hospital
United States

Aspirins legacy on cancer and overall benefit: risk balance over a 15-year horizon 3U01CA301988-02S1 Asad Umar, D.V.M., Ph.D.
Washington, Karla

Washington University
United States

Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care 5R01CA258311-05 Brennan Streck, Ph.D., RN, M.P.H.
Washington, Karla

Washington University
United States

Problem-Solving Therapy for Cancer Caregivers: A Randomized Clinical Trial in Outpatient Palliative Care 5R01CA258311-05 Brennan Streck, Ph.D., RN, M.P.H.
Watt, Gordon Patrick

Netherlands Cancer Institute
United States

Quantitative background parenchymal enhancement, measured on contrast-enhanced mammogram, as a novel marker of breast cancer risk 3R37CA284134-03S1 Claire Zhu, Ph.D.
Webster, Nicholas J

Veterans Medical Research Fdn/San Diego
United States

The Effect of Time-Restricted Eating on the Efficiency of Chemo- and Hormonal-Therapy in Breast Cancer 5R21CA288777-02 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Webster, Nicholas J

University Of California, San Diego
United States

Time-restricted feeding and breast cancer 5R01CA196853-09 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Wei, Lei

Roswell Park Cancer Institute Corp
United States

Advancing skin cancer prevention by tackling UV-induced clonogenic mutations 5R01CA255242-05 Wendy Wang, Ph.D., M.Sc.
Welsh, Joellen

State University Of New York At Albany
United States

Vitamin K: Body Pools and Function in Breast Cancer 5R01CA258231-05 Young Kim, Ph.D.
Whitman, Eric

Atlantic Health System, Inc.
United States

The Atlantic Health Cancer Consortium Community Oncology Research Program (AHCC Corp) 3UG1CA239772-06S1 Vanessa A. White, M.P.H.
Whitman, Eric

Atlantic Health System, Inc.
United States

The Atlantic Health Cancer Consortium Community Oncology Research Program (AHCC Corp) 3UG1CA239772-06S1 Vanessa A. White, M.P.H.
Wildman-Tobriner, Benjamin

Duke University
United States

AI for Differentiation of Low vs High Risk Thyroid Nodules on Ultrasound 1R01CA297227-01A1 Wendy Wang, Ph.D., M.Sc.
Wilkin, Timothy J.

University Of California, San Diego
United States

Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub) 5UG1CA275414-05 Maria Silvina Frech, Ph.D., M.S.
Williams, Paige L

Harvard University D/B/A Harvard School Of Public Health
United States

Pediatric HIV/AIDS Cohort Study (PHACS) 2020 3P01HD103133-05S1 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Wilson, Michael R

Wayne State University
United States

Does obesity influence protein quality control in endometrial cancer? 5R00CA252152-05 Amit Kumar, Ph.D.
Winer, Rachel L.

University Of Washington
United States

The CASCADE CLIMB: Cervical cancer prevention in women Living with HIV research Mobilization Base 5UG1CA275402-04 Maria Silvina Frech, Ph.D., M.S.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554