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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Vinciguerra, Vincent P

Feinstein Institute For Medical Research
United States

Northwell Health NCORP 3UG1CA189850-11S2 Vanessa A. White, M.P.H.
Wagner, Lynne I.

Ecog-Acrin Medical Research Foundation
United States

ECOG-ACRIN NCORP Research Base 3UG1CA189828-11S2 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wagner, Lynne I.

Ecog-Acrin Medical Research Foundation
United States

ECOG-ACRIN NCORP Research Base 3UG1CA189828-11S2 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Wallace, Douglas C

Children'S Hosp Of Philadelphia
United States

Anti-tumor immunity and intestinal microbiota are modulated by mitochondrial DNA 5R01CA259635-04 Young Kim, Ph.D.
Wang, Hsiao-Lan

University Of Alabama At Birmingham
United States

A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment 5R01CA244947-06 Goli Samimi, Ph.D., M.P.H.
Wang, Tza-Huei Jeff

Johns Hopkins University
United States

A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies 5R33CA272321-03 Christos Patriotis, Ph.D., M.Sc.
Wang, Kai

Massachusetts General Hospital
United States

Dietary prevention for colorectal cancer: targeting the bile acid/gut microbiome axis 4R00CA283146-03 Amit Kumar, Ph.D.
Wang, Tza-Huei Jeff

Johns Hopkins University
United States

Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women 5R01CA260628-05 Christos Patriotis, Ph.D., M.Sc.
Wang, Linghua

University Of Tx Md Anderson Can Ctr
United States

Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D) 4U01CA294518-02 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Wang, Jing

New York University School Of Medicine
United States

Optimizing the use of ketamine to reduce chronic postsurgical pain 3UH3CA261067-05S1 Brennan Streck, Ph.D., RN, M.P.H.
Wang, Hsiao-Lan

University Of Alabama At Birmingham
United States

A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment 5R01CA244947-06 Goli Samimi, Ph.D., M.P.H.
Wang, Thomas D

University Of Michigan At Ann Arbor
United States

Early detection of colorectal cancer in the traditional and serrated pathways 5R01CA249851-05 Guillermo Marquez, Ph.D.
Wang, Jing

New York University School Of Medicine
United States

Optimizing the use of ketamine to reduce chronic postsurgical pain 3UH3CA261067-05S1 Brennan Streck, Ph.D., RN, M.P.H.
Wang, Thomas D

University Of Michigan At Ann Arbor
United States

Peptide multimer for early detection of hepatocellular carcinoma 5R01CA285303-02 Guillermo Marquez, Ph.D.
Wang, Hsiao-Lan

University Of Alabama At Birmingham
United States

A Motion Exergaming Approach to Promote Self-Managing Fatigue and Pain after Head and Neck Cancer Treatment 5R01CA244947-06 Goli Samimi, Ph.D., M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554