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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Taratula, Oleh

Oregon State University
United States

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia 5R37CA234006-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Taratula, Oleh

Oregon State University
United States

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia 5R37CA234006-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Tayob, Nabihah

Dana-Farber Cancer Inst
United States

Biomarker screening algorithms for the improved early detection of hepatocellular carcinoma 5R01CA230503-07 Nicholas Hodges, Ph.D.
Tearney, Guillermo J

Massachusetts General Hospital
United States

Colorectal Cancer Screening with Optical Coherence Tomography 5R01CA280972-02 Matthew Young, Ph.D.
Temprosa, Marinella

George Washington University
United States

22/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) – Biostatistics Center 2U01DK048489-28 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Tennis, Meredith A

University Of Colorado Denver
United States

Modeling lung squamous cell carcinoma premalignancy and prevention 1R01CA298925-01
Tennis, Meredith A

University Of Colorado Denver
United States

Persistence and regression in lung premalignant lesions 1R01CA289576-01A1 Malgorzata Wojtowicz, M.D.
Terry, Kathryn L.

Brigham And Women'S Hospital
United States

Changing Contraceptive Patterns and Ovarian Cancer Risk 5R01CA258679-05 Goli Samimi, Ph.D., M.P.H.
Tewari, Ashutosh K

Icahn School Of Medicine At Mount Sinai
United States

Artificial intelligence enabled Stroma-Weighted Automated Grading system to improve risk stratification in Black Men 1R01CA290438-01A1 Indu Kohaar, Ph.D., M.Phil., M.Sc.
Thakur, Mathew Laxman

Thomas Jefferson University
United States

Noninvasive, Uniplex, Molecular, Pathomic Urinary Assay for Detection of Prostate Cancer 5R01CA249921-05
Thangaraju, Muthusamy

Augusta University
United States

Bacteria-derived xenobiotics in colon cancer prevention: Link to GPR109A and colonic ketogenesis 5R01CA275840-03
Thompson, Patricia Ann

University Of Arizona
United States

University of Arizona Cancer Prevention Clinical Trials Network 2UG1CA242596-07 Donald Johnsey
Thompson, Patricia Ann

State University New York Stony Brook
United States

Three-Arm randomized trial comparing the effect of aspirin, sulindac or no treatment control on breast density in patients with elevated breast cancer risk 5R01CA235720-05 Edward Sauter, M.D., Ph.D.
Tollefsbol, Trygve O

University Of Alabama At Birmingham
United States

Combinatorial epigenetic-based prevention of breast cancer 5R01CA178441-10 Gabriela Riscuta, M.D., CNS
Tong, Frank

Vanderbilt University
United States

Learning the visual and cognitive bases of lung nodule detection 5R01CA240274-05

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554