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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Smith, Jennifer Susan

Univ Of North Carolina Chapel Hill
United States

UNC CASCADE Network Research Base 5UG1CA275403-04 Maria Silvina Frech, Ph.D., M.S.
Smith, Ellen Mary Lavoie

University Of Alabama At Birmingham
United States

Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study 5R01CA235726-07 Brennan Streck, Ph.D., RN, M.P.H.
Smith, Ellen Mary Lavoie

University Of Alabama At Birmingham
United States

Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study 5R01CA235726-07 Brennan Streck, Ph.D., RN, M.P.H.
Sohl, Stephanie Jean

Wake Forest University Health Sciences
United States

REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE) 5R01CA266995-04 Goli Samimi, Ph.D., M.P.H.
Sohl, Stephanie Jean

Wake Forest University Health Sciences
United States

REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE) 5R01CA266995-04 Goli Samimi, Ph.D., M.P.H.
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.
Somers, Tamara J

Duke University
United States

A Mobile Health Behavioral Pain Intervention Protocol for Breast Cancer Patients with Pain in Medically Underserved Communities: A Randomized Controlled Trial 5R01CA237892-05 Brennan Streck, Ph.D., RN, M.P.H.
Song, Ming

University Of Louisville
United States

Dietary fructose and NASH/HCC progression 5R21CA290420-02 Amit Kumar, Ph.D.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Sorror, Mohamed

Fred Hutchinson Cancer Center
United States

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality 5R01CA227092-06 Marjorie Perloff, M.D.
Spector, Tim

King'S College London
United States

PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors 1OT2CA297289-01 Asad Umar, D.V.M., Ph.D.
Spiegel, Brennan

Cedars-Sinai Medical Center
United States

Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes 5R01CA252211-05 Rachel Altshuler, Ph.D.
Spiegel, Brennan

Cedars-Sinai Medical Center
United States

Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes 5R01CA252211-05 Rachel Altshuler, Ph.D.
Stachler, Matthew D

University Of California, San Francisco
United States

Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus 3R37CA269649-03S1 Matthew Young, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554