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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Santomasso, Bianca Denise

Sloan-Kettering Inst Can Research
United States

Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy 5R01CA293922-02 Monica Epstein, B.S.N., RN, OCN
Santomasso, Bianca Denise

Sloan-Kettering Inst Can Research
United States

Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy 5R01CA293922-02 Monica Epstein, B.S.N., RN, OCN
Santos-Reyes, Luis Javier

Comprehensive Cancer Center/ Univ/Pr
United States

Puerto Rico NCI Community Oncology Research Program (Puerto Rico NCORP) 3UG1CA189862-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Santos-Reyes, Luis Javier

Comprehensive Cancer Center/ Univ/Pr
United States

Puerto Rico NCI Community Oncology Research Program (Puerto Rico NCORP) 3UG1CA189862-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Saphner, Thomas J

Aurora Health Care, Inc.
United States

Aurora NCORP Community Site 3UG1CA190140-11S1 Vanessa A. White, M.P.H.
Saphner, Thomas J

Aurora Health Care, Inc.
United States

Aurora NCORP Community Site 3UG1CA190140-11S1 Vanessa A. White, M.P.H.
Schallenkamp, John M.

Montana Cancer Consortium
United States

Montana Cancer Consortium: An Inclusive and Collaborative Approach to Clinical Trial Accrual and Cancer Care Delivery Research across Montana, Idaho and Wyoming 3UG1CA189872-11S1 Vanessa A. White, M.P.H.
Schallenkamp, John M.

Montana Cancer Consortium
United States

Montana Cancer Consortium: An Inclusive and Collaborative Approach to Clinical Trial Accrual and Cancer Care Delivery Research across Montana, Idaho and Wyoming 3UG1CA189872-11S1 Vanessa A. White, M.P.H.
Schaverien, Mark V

University Of Tx Md Anderson Can Ctr
United States

Lymphedema Prevention Through Immediate Lymphatic Reconstruction 5R01CA292908-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Schaverien, Mark V

University Of Tx Md Anderson Can Ctr
United States

Lymphedema Prevention Through Immediate Lymphatic Reconstruction 5R01CA292908-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Schedin, Pepper J

Oregon Health & Science University
United States

NSAIDs During Postpartum Involution for Breast Cancer Chemoprevention 5R01CA169175-11 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Schenker, Yael

University Of Pittsburgh At Pittsburgh
United States

Patient-centered and efficacious advance care planning in cancer: the PEACe comparative effectiveness trial 5R01CA235730-06 Brennan Streck, Ph.D., RN, M.P.H.
Schmidt, Christian Maximillian

Indiana University Indianapolis
United States

Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic Cancer 5U01CA239522-05 Claire Zhu, Ph.D.
Schmit, Stephanie L.

Cleveland Clinic Lerner Com-Cwru
United States

Variation in tumor-associated immune profiles and colorectal cancer outcomes 5R01CA248931-05 Asad Umar, D.V.M., Ph.D.
Schoen, Robert E.

University Of Pittsburgh At Pittsburgh
United States

Blood-Based Testing for Advanced Adenoma 5U01CA271884-04 Matthew Young, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554