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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Papachristodoulou, Alexandros

Rutgers Biomedical And Health Sciences
United States

Investigating mitochondrial dysfunction in high-risk prostate cancer 4R00CA276713-03 Vignesh Gunasekharan, Ph.D.
Papadopoulos, Nickolas

Johns Hopkins University
United States

Multi-analyte Approach for Earlier Detection of Cancers in Non Plasma Biofluids 5U01CA230691-08 Nicholas Hodges, Ph.D.
Park, Youngkyu

Cold Spring Harbor Laboratory
United States

Preclinical Models for Cancer Therapeutic Development 5R50CA211506-10 Marjorie Perloff, M.D.
Paskett, Electra D.

Alliance Nctn Foundation
United States

Alliance NCORP Research Base 3UG1CA189823-11S3 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Paskett, Electra D.

Alliance Nctn Foundation
United States

Alliance NCORP Research Base 3UG1CA189823-11S3 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Paulovich, Amanda G

Fred Hutchinson Cancer Center
United States

Breast-cancer focused biomarker characterization center employing targeted mass spec assays in a CLIA environment 5U2CCA271873-03 Sidney Fu, M.D.
Paulson, Thomas G

Fred Hutchinson Cancer Center
United States

The microbiome ecosystem of Barrett's esophagus and progression to cancer 5R21CA259687-02 Matthew Young, Ph.D.
Paus, Ralf

University Of Miami School Of Medicine
United States

Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia 1R21CA277418-01A1 Rachel Altshuler, Ph.D.
Paus, Ralf

University Of Miami School Of Medicine
United States

Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia 1R21CA277418-01A1 Rachel Altshuler, Ph.D.
Pena, Maria Marjorette

University Of South Carolina At Columbia
United States

The Role of Early Life Exposure to Antibiotics on Risk of Early Onset Colorectal Cancer 1R21CA281729-01A1
Penedo, Frank J

University Of Miami Coral Gables
United States

eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant Patients 4R33CA263335-03 Asad Umar, D.V.M., Ph.D.
Penedo, Frank J

University Of Miami Coral Gables
United States

eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant Patients 4R33CA263335-03 Asad Umar, D.V.M., Ph.D.
Peppone, Luke Joseph

University Of Rochester
United States

High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients 5R01CA258349-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Peppone, Luke Joseph

University Of Rochester
United States

High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients 5R01CA258349-04 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Perez-Lougee, Giselle Katiria

Massachusetts General Hospital
United States

Thriving Beyond Treatment: A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship 1R37CA303094-01 Marjorie Perloff, M.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554