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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Nelson, Randy J.

West Virginia University
United States

Mechanism Underlying Sleep Disruption by Mammary Tumors 5R21CA276027-02 Marjorie Perloff, M.D.
Neslund-Dudas, Christine Marie

Henry Ford Health + Michigan State University Health Sciences
United States

HFH-MSU CSRN ACCrual Enrollment and Screening Site 3UG1CA287007-02S1 Elyse LeeVan, M.D., M.P.H.
Nguyen, Sang Minh

Vanderbilt University Medical Center
United States

Gut Microbiome Profiles in Association with Breast Cancer Recurrence and Mortality 1R03CA292953-01 Gabriela Riscuta, M.D., CNS
Nicolson, Fay

Dana-Farber Cancer Inst
United States

SESORRS endoscopy for the staging and evaluation of colorectal cancer 5R00CA266921-04
NINA, BHARDWAJ,

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States

Immune determinants modulating cancer development in Lynch Syndrome 1UG3CA290517-01
Noble, Mark D

University Of Rochester
United States

Prevention and treatment of paclitaxel-induced peripheral neuropathy 5R21CA277447-02 Rachel Altshuler, Ph.D.
Noble, Mark D

University Of Rochester
United States

Prevention and treatment of paclitaxel-induced peripheral neuropathy 5R21CA277447-02 Rachel Altshuler, Ph.D.
Nolan, Michael Warren

North Carolina State University Raleigh
United States

Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer 5R37CA248797-05 Asad Umar, D.V.M., Ph.D.
Nolan, Michael Warren

North Carolina State University Raleigh
United States

Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer 5R37CA248797-05 Asad Umar, D.V.M., Ph.D.
Nyamathi, Adeline M

University Of California-Irvine
United States

Secondary Cervical Cancer Prevention of Vulnerable Women with HPV and HIV Co-infection in India 3R01CA285063-03S2 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Oberg, Ann Laura

Mayo Clinic Rochester
United States

Management and Data Coordination Unit for PCDC 5U24CA274496-04 Guillermo Marquez, Ph.D.
Ochoa, Augusto C.

Lsu Health Sciences Center
United States

Gulf South Clinical Trials Network (Gulf South NCORP) 3UG1CA189854-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ochoa, Augusto C.

Lsu Health Sciences Center
United States

Gulf South Clinical Trials Network (Gulf South NCORP) 3UG1CA189854-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Olopade, Olufunmilayo F.

University Of Chicago
United States

The Funding Mechanism of the Pilot Trial 5R01CA276652-03 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ondrey, Frank G.

University Of Minnesota
United States

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia 5R01CA254270-04 Malgorzata Wojtowicz, M.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554