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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Bartolini, Francesca

Columbia University Health Sciences
United States

Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN 5R01CA279401-02 Rachel Altshuler, Ph.D.
Barton, Jennifer Kehlet

University Of Arizona
United States

Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers 5R01CA260399-04 Guillermo Marquez, Ph.D.
Basu, Partha

International Agency For Res On Cancer
United States

A novel, one stop, affordable, point of care and artificial intelligence supported system of screening, triage and treatment selection for cervical cancer and precancer in the LMICs 3R37CA275824-03S2 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Bedrosian, Isabelle

University Of Tx Md Anderson Can Ctr
United States

Chimeric RNA driven neopeptide vaccine for prevention of breast cancer in germline BRCA1/2 carriers 1UG3CA290454-01A1 Altaf Mohammed, Ph.D.
Beretta, Laura

University Of Tx Md Anderson Can Ctr
United States

Early Detection of Hepatocellular Carcinoma 5R01CA195524-09 Matthew Young, Ph.D.
Bergan, Raymond C.

University Of Nebraska Medical Center
United States

Preventing invasive prostate cancer 3R01CA276846-03S1 John Clifford, Ph.D.
Bertozzi, Carolyn

Stanford University
United States

Chemical Glycoproteomics 5R01CA200423-22 Guillermo Marquez, Ph.D.
Bettegowda, Chetan

Johns Hopkins University
United States

Interrogating malignant gliomas using released tumor DNA in cerebrospinal fluid 5R37CA230400-07 Sidney Fu, M.D.
Bhatt, Vijaya Raj

University Of Nebraska Medical Center
United States

Aging trajectories and outcomes of older adults with acute myeloid leukemia 5R37CA276928-03 Brennan Streck, Ph.D., RN, M.P.H.
Bhatt, Vijaya Raj

University Of Nebraska Medical Center
United States

Aging trajectories and outcomes of older adults with acute myeloid leukemia 5R37CA276928-03 Brennan Streck, Ph.D., RN, M.P.H.
Bissonnette, Bruce Marc

University Of Chicago
United States

A non-invasive blood test for multi-cancer detection and determination of tissue of origin preceding overt cancer diagnosis 1U01CA297685-01 Claire Zhu, Ph.D.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Blanke, Charles D.

Oregon Health & Science University
United States

SWOG NCORP Research Base 3UG1CA189974-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554