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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Madeleine, Margaret M

Fred Hutchinson Cancer Center
United States

Colaboracion Evita: HPV-Related Cancer Prevention Partnership Center 3U54CA242977-07S4 Maria Silvina Frech, Ph.D., M.S.
Mahan, Kristin Eckel

University Of Texas Hlth Sci Ctr Houston
United States

Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain 1R21CA292148-01 John Clifford, Ph.D.
Mahan, Kristin Eckel

University Of Texas Hlth Sci Ctr Houston
United States

Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain 1R21CA292148-01 John Clifford, Ph.D.
Maitra, Anirban

New York University School Of Medicine
United States

Clinical Validation Center for Early Detection of Pancreatic Cancer 7U01CA200468-09 Matthew Young, Ph.D.
Maitra, Anirban

New York University School Of Medicine
United States

Clinical Validation Center for Early Detection of Pancreatic Cancer 7U01CA200468-09 Matthew Young, Ph.D.
Majumder, Shounak

Mayo Clinic Rochester
United States

Mayo Clinic Prospective Resource for Biomarker Validation and Early Detection of Pancreatic Cancer 5U01CA210138-09 Matthew Young, Ph.D.
Maldonado, Fabien

Vanderbilt University Medical Center
United States

Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures 5R01CA253923-05
Mallery, Susan R

Ohio State University
United States

Assessment of Chemopreventive Effects of a Mucoadhesive Fenretinide Patch on Premalignant Oral Epithelial Lesions 5R01CA227273-06 Malgorzata Wojtowicz, M.D.
Mallery, Susan R

Ohio State University
United States

Formulation, Evaluation, and Phase 0 Trial of Nanoparticle Releasing Oral Thin Film for OSCC Chemoprevention 5R01CA258757-04 Malgorzata Wojtowicz, M.D.
Mallick, Parag Kumar

Stanford University
United States

Pathomic Predictors of Prostate Cancer Progression 5R01CA249899-05
Mana, Miyeko

Arizona State University-Tempe Campus
United States

Influence of developmental programming in adult stem cells and cancer 1R01CA301086-01 Young Kim, Ph.D.
Mao, Jun J

Sloan-Kettering Inst Can Research
United States

Enhanced Pain Coping in Cancer (EPIC) 5R01CA285746-02 Rachel Altshuler, Ph.D.
Mao, Jun J

Sloan-Kettering Inst Can Research
United States

Enhanced Pain Coping in Cancer (EPIC) 5R01CA285746-02 Rachel Altshuler, Ph.D.
Marchand, Loic Le

University Of Hawaii At Manoa
United States

Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial 5R01CA258179-05 Gabriela Riscuta, M.D., CNS
Marchetti, Dario

University Of New Mexico Health Scis Ctr
United States

Mechanisms of melanoma brain metastasis by CTCs isolated from patients' blood and CSF 5R01CA216991-07 Matthew Young, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554