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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.
Linnes, Jacqueline

Purdue University
United States

Point-of-care screening test for early cervical cancer detection 5R01CA246315-05 Christos Patriotis, Ph.D., M.Sc.
Lipkin, Steven M

Weill Medical Coll Of Cornell Univ
United States

CAP-IT Center for LNP RNA Immunoprevention 5U54CA272688-04 John Clifford, Ph.D.
Liu, Changchun

University Of Connecticut Sch Of Med/Dnt
United States

Low-Cost CRISPR-on-Paper for Cervical Cancer Screening at the Point of Care 3U01CA269147-04S1 Christos Patriotis, Ph.D., M.Sc.
Liu, Yang

University Of Illinois At Urbana-Champaign
United States

Imaging nanoscale chromatin folding in early carcinogenesis 5R01CA254112-07 Matthew Young, Ph.D.
Livneh, Zvi

Weizmann Institute Of Science
United States

Analysis of the predictability of lung cancer using DNA Repair functional assays and cryopreserved blood samples of the PLCO prospective cohort 5U01CA279001-03 Claire Zhu, Ph.D.
Lokshin, Anna E

University Of Pittsburgh At Pittsburgh
United States

Development of Novel Ovarian Cancer Biomarkers for Early Detection Algorithms 5R01CA247220-05 Christos Patriotis, Ph.D., M.Sc.
Lokshin, Anna E

University Of Pittsburgh At Pittsburgh
United States

Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer 5R01CA254036-05 Matthew Young, Ph.D.
Lowry, Kathryn Paige

University Of Washington
United States

Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations 5R37CA292399-02 Claire Zhu, Ph.D.
Lu, Junxuan

Pennsylvania State Univ Hershey Med Ctr
United States

Early clinial trials for Angelica herbal supplements for prostate cancer interception 4R01CA260901-04 Gabriela Riscuta, M.D., CNS
Lubman, David M.

University Of Michigan At Ann Arbor
United States

Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach 5R01CA160254-14 Matthew Young, Ph.D.
Lyden, David Charles

Weill Medical Coll Of Cornell Univ
United States

Application of 4D proteomics and super-resolution microscopy in extracellular vesicle and particle-borne biomarker discovery for early pancreatic cancer detection 5R01CA218513-08 Matthew Young, Ph.D.
Maclean, Paul S.

University Of Colorado Denver
United States

Novel dietary interventions for reducing obesity-associated breast cancer 5R01CA258766-04 Young Kim, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554