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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Lesser, Glenn J

Wake Forest University Health Sciences
United States

Wake Forest NCORP Research Base 3UG1CA189824-11S2 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Li, Bing

University Of Iowa
United States

E-FABP mediates n-3 fatty acid-induced tumor prevention through epigenetic control of immune cell differentiation and function 5R01CA180986-11 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Li, Yong

Baylor College Of Medicine
United States

Cancer Prevention-Interception Against MGUS Progression 5U54CA272691-03 Anda Vlad, M.D., Ph.D.
Li, Feng

University Of California Los Angeles
United States

Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer. 5R21CA283665-02 Guillermo Marquez, Ph.D.
Li, Chi

University Of Louisville
United States

A lung cancer vaccine based on exosomes of induced pluripotent stem cells 1R21CA280453-01 John Clifford, Ph.D.
Li, Christopher I

Fred Hutchinson Cancer Center
United States

Fred Hutchinson Breast Cancer Clinical Validation Center 5U01CA152637-15 Sidney Fu, M.D.
Li, Christopher I

Fred Hutchinson Cancer Center
United States

Fred Hutchinson Breast Cancer Clinical Validation Center 5U01CA152637-15 Sidney Fu, M.D.
Li, Bo

Children'S Hosp Of Philadelphia
United States

Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis 5R01CA258524-05 Christos Patriotis, Ph.D., M.Sc.
Li, Debiao

Cedars-Sinai Medical Center
United States

Predicting Pancreatic Ductal Adenocarcinoma (PDAC) Through Artificial Intelligence Analysis of Pre-Diagnostic CT Images 5R01CA260955-05 Matthew Young, Ph.D.
Liang, Han

University Of Tx Md Anderson Can Ctr
United States

The Cancer Proteome Atlas: an Integrated Bioinformatics Resource for Functional Cancer Proteomic Data 5U24CA264128-04 Christos Patriotis, Ph.D., M.Sc.
Ligibel, Jennifer A.

Dana-Farber Cancer Inst
United States

Distance-based Exercise to preserve Function and prevENt Disability (DEFEND) 5U34CA293568-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ligibel, Jennifer A.

Dana-Farber Cancer Inst
United States

Distance-based Exercise to preserve Function and prevENt Disability (DEFEND) 5U34CA293568-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ligibel, Jennifer A.

Dana-Farber Cancer Inst
United States

Distance-based Exercise to preserve Function and prevENt Disability (DEFEND) 5U34CA293568-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Lin, Jia-Ren

Harvard Medical School
United States

Advancing technologies for the collection and analysis of high dimensional immunoprofiles and tumor images 5R50CA274277-04 Guillermo Marquez, Ph.D.
Lindau, Stacy Tessler

University Of Chicago
United States

Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy 5R01CA281301-03 Marjorie Perloff, M.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554