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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Langevin, Anne-Marie R.

University Of Texas Hlth Science Center
United States

Texas Pediatric NCORP 3UG1CA189855-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Langevin, Anne-Marie R.

University Of Texas Hlth Science Center
United States

Texas Pediatric NCORP 3UG1CA189855-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Leal, Ana Sofia Mendes

Indiana University Indianapolis
United States

Nrf2, immune cells and lung cancer 7R01CA226690-06 Marjorie Perloff, M.D.
Lee, Jeffrey Kuang Zou

Kaiser Foundation Research Institute
United States

Vanguard Study Administrative Supplement 3UG1CA287011-02S1 Elyse LeeVan, M.D., M.P.H.
Lee, Hakho

Massachusetts General Hospital
United States

Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic Array 5U01CA284982-03 Nicholas Hodges, Ph.D.
Lee, Juhun

University Of Pittsburgh At Pittsburgh
United States

Detecting Mammographically-Occult Cancer in Women with Dense Breasts Using Digital Breast Tomosynthesis 5R01CA269540-03 Sidney Fu, M.D.
Lee, Richard T

Beckman Research Institute/City Of Hope
United States

A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy 1R21CA260447-01A1 Rachel Altshuler, Ph.D.
Lee, Richard T

Beckman Research Institute/City Of Hope
United States

A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy 1R21CA260447-01A1 Rachel Altshuler, Ph.D.
Lehto, Rebecca H

Henry Ford Health + Michigan State University Health Sciences
United States

Support for bereaved friend and family caregivers of cancer patients 1R03CA282943-01A1 Brennan Streck, Ph.D., RN, M.P.H.
Lehto, Rebecca H

Henry Ford Health + Michigan State University Health Sciences
United States

Support for bereaved friend and family caregivers of cancer patients 1R03CA282943-01A1 Brennan Streck, Ph.D., RN, M.P.H.
Lehto, Rebecca H

Henry Ford Health + Michigan State University Health Sciences
United States

Support for bereaved friend and family caregivers of cancer patients 1R03CA282943-01A1 Brennan Streck, Ph.D., RN, M.P.H.
Lenburg, Marc Elliott

Boston University Medical Campus
United States

The Boston University - UCLA Lung Cancer Biomarker Characterization Center 5U2CCA271898-04 Guillermo Marquez, Ph.D.
Lesch, Bluma J

Yale University
United States

Defining signatures of epigenetic sensitization to lung cancer in a mouse model 5R21CA288677-02 Guillermo Marquez, Ph.D.
Leslie, Kimberly K.

University Of New Mexico Health Scis Ctr
United States

Advancing Hormone Therapy for Endometrial Cancer 1P01CA278735-01A1 Goli Samimi, Ph.D., M.P.H.
Lesser, Glenn J

Wake Forest University Health Sciences
United States

Wake Forest NCORP Research Base 3UG1CA189824-11S2 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554