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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Khasabov, Sergey G

University Of Minnesota
United States

Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling 5R01CA263777-05 Rachel Altshuler, Ph.D.
Kibel, Adam S

Brigham And Women'S Hospital
United States

Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer 5U01CA268810-03 Guillermo Marquez, Ph.D.
Kim, Michelle Kang

Cleveland Clinic Lerner Com-Cwru
United States

Assessing feasibility of gastric cancer screening in the US 1R37CA300540-01 Claire Zhu, Ph.D.
Kim, Hyung L

Cedars-Sinai Medical Center
United States

Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer 5R01CA280060-03 Howard L. Parnes, M.D.
Kirkwood, Kimberly Saunders

University Of California, San Francisco
United States

Using microvolumetric cyst fluid proteolysis for early detection of pancreatic cancer 5U01CA282269-02 Matthew Young, Ph.D.
Kisiel, John

Mayo Clinic Rochester
United States

Multi-cancer Early Detection 2R01CA214679-08 Matthew Young, Ph.D.
Kleckner, Amber Simmons

University Of Maryland Baltimore
United States

Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies 5R01CA284082-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Kleckner, Amber Simmons

University Of Maryland Baltimore
United States

Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies 5R01CA284082-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Klein, Alison P

Johns Hopkins University
United States

Improving Management of patients at High Risk of Pancreatic Cancer 1R01CA299421-01 Matthew Young, Ph.D.
Klopp, Ann

University Of Tx Md Anderson Can Ctr
United States

Defining a globally accessible and pragmatic predictive signature (GAPPS) for locally advanced cervical cancer 1R01CA301124-01 Goli Samimi, Ph.D., M.P.H.
Knoerl, Robert James

University Of Michigan At Ann Arbor
United States

Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors. 5R34CA286712-02 Goli Samimi, Ph.D., M.P.H.
Knoerl, Robert James

University Of Michigan At Ann Arbor
United States

Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors. 5R34CA286712-02 Goli Samimi, Ph.D., M.P.H.
Knoerl, Robert James

University Of Michigan At Ann Arbor
United States

Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors. 5R34CA286712-02 Goli Samimi, Ph.D., M.P.H.
Knoerl, Robert James

University Of Michigan At Ann Arbor
United States

Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors. 5R34CA286712-02 Goli Samimi, Ph.D., M.P.H.
Kober, Kord Michael

University Of California, San Francisco
United States

An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach 5R37CA233774-07 Brandy Heckman-Stoddard, Ph.D., M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554