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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.
Kanarek, Naama

Boston Children'S Hospital
United States

Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF 5R01CA282477-02 John Clifford, Ph.D.
Kanetsky, Peter A

H. Lee Moffitt Cancer Ctr & Res Inst
United States

A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers 5R01CA291735-02 Claire Zhu, Ph.D.
Kang, Dongkyun

University Of Arizona
United States

Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy 1R01CA301271-01 Rachel Altshuler, Ph.D.
Kang, Dongkyun

University Of Arizona
United States

Non-invasive, quantitative microscopic biomarkers for chemotherapy-induced peripheral neuropathy 1R01CA301271-01 Rachel Altshuler, Ph.D.
Kanwal, Fasiha

Baylor College Of Medicine
United States

Risk Stratification for and Early Detection of Liver Cancer 5U01CA230997-08 Sidney Fu, M.D.
Kassie, Fekadu

University Of Minnesota
United States

Targeting tumor cell mitochondria for the prevention and treatment of lung cancer 1R01CA285608-01A1
Kelleher, Sarah

Duke University
United States

Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients 5R01CA291888-02 Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah

Duke University
United States

Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients 5R01CA291888-02 Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah

Duke University
United States

Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients 5R01CA291888-02 Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah

Duke University
United States

Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings 5R21CA273832-02 Brennan Streck, Ph.D., RN, M.P.H.
Kelleher, Sarah

Duke University
United States

Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings 5R21CA273832-02 Brennan Streck, Ph.D., RN, M.P.H.
Khan, Seema Ahsan

Northwestern University At Chicago
United States

Northwestern Cancer Prevention Consortium 2UG1CA242643-07 Donald Johnsey
Khan, Seema Ahsan

Northwestern University At Chicago
United States

Determinants of transdermal drug delivery to the normal and the radiated breast 5R01CA235647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Khasabov, Sergey G

University Of Minnesota
United States

Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling 5R01CA263777-05 Rachel Altshuler, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554