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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.
Jaslowski, Anthony J

St. Vincent Hospital
United States

Cancer Research of Wisconsin and Northern Michigan (CROWN) Consortium 3UG1CA239769-06S1 Vanessa A. White, M.P.H.
Jaslowski, Anthony J

St. Vincent Hospital
United States

Cancer Research of Wisconsin and Northern Michigan (CROWN) Consortium 3UG1CA239769-06S1 Vanessa A. White, M.P.H.
Ji, Hanlee P

Stanford University
United States

Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification 5P01CA265772-03 Asad Umar, D.V.M., Ph.D.
Ji, Hanlee P

Stanford University
United States

Single-molecule nanopore-based identification of methylome signatures in cfDNA for early colorectal cancer detection 5U01CA282212-02 Claire Zhu, Ph.D.
Jiang, Feng

Biotarget Dx Llc
United States

Plasma microRNA biomarkers for lung cancer diagnosis 7UH3CA251139-05 Guillermo Marquez, Ph.D.
Jiang, Qing

Purdue University
United States

Anti-cancer effects of tocotrienols and a carboxychromanol in an innovative colon cancer model 5R03CA283236-02 Amit Kumar, Ph.D.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer 5R34CA289918-02 Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer 5R34CA289918-02 Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer 5R34CA289918-02 Brennan Streck, Ph.D., RN, M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue 5R01CA214647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Jim, Heather S.L.

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Randomized Placebo Controlled Trial of Bupropion for Cancer Related Fatigue 5R01CA214647-05 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Jobin, Christian

University Of Florida
United States

Interaction between dietary taurine and microbiota sulfur metabolism in the development of colorectal cancer 1R01CA296643-01 Young Kim, Ph.D.
John, Esther M.

Stanford University
United States

Stress, inflammation, and health-related quality of life of long-term breast cancer survivors 1R21CA290430-01 Brennan Streck, Ph.D., RN, M.P.H.
John, Esther M.

Stanford University
United States

Stress, inflammation, and health-related quality of life of long-term breast cancer survivors 1R21CA290430-01 Brennan Streck, Ph.D., RN, M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554