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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Hutson, Alan David

Roswell Park Cancer Institute Corp
United States

Cancer Immunoprevention Network (CIP-Net) Resource Coordinating Center 1U24CA305623-01 Altaf Mohammed, Ph.D.
Huttenhower, Curtis

Broad Institute, Inc.
United States

PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors 3OT2CA297578-01S1 Asad Umar, D.V.M., Ph.D.
Ibsen, Stuart Duncan

Oregon Health & Science University
United States

Distinguishing Pancreatic Cancer from Benign Pancreatic Disease using Nanoparticle-based Biomarkers 5R37CA258787-04 Matthew Young, Ph.D.
Im, Eun-Ok

University Of Texas At Austin
United States

Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors 5R33CA280979-04 Brennan Streck, Ph.D., RN, M.P.H.
Im, Eun-Ok

University Of Texas At Austin
United States

Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors 5R33CA280979-04 Brennan Streck, Ph.D., RN, M.P.H.
Infante, Rodney E

Ut Southwestern Medical Center
United States

Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia 3R01CA266900-04S1 Marjorie Perloff, M.D.
Infante, Rodney E

Ut Southwestern Medical Center
United States

Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia 3R01CA266900-04S1 Marjorie Perloff, M.D.
Infante, Rodney E

Ut Southwestern Medical Center
United States

Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia 3R01CA266900-04S1 Marjorie Perloff, M.D.
Irvin, William J

Southeast Clinical Oncol Res Consortium
United States

NCI Community Oncology Research Program 2025 Extension Request 3UG1CA189858-11S1 Vanessa A. White, M.P.H.
Irvin, William J

Southeast Clinical Oncol Res Consortium
United States

NCI Community Oncology Research Program 2025 Extension Request 3UG1CA189858-11S1 Vanessa A. White, M.P.H.
Iwelunmor, Juliet

Washington University
United States

Innovative Rapid Enabling, Affordable, point-of-Care HPV Self-Testing Strategy (I-REACH) 3U01CA279863-04S1 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Iyer, Prasad G.

Mayo Clinic Arizona
United States

Minimally Invasive Molecular Approaches for the Detection of Barrett’s Esophagus and Esophageal Adenocarcinoma 2R01CA241164-07 Matthew Young, Ph.D.
Jacob, Jennifer B

Henry Ford Health + Michigan State University Health Sciences
United States

Defining Cancer Intervention Targets by Functional Genomics Analysis of Outbred F1 Mice 5R01CA278818-03
James, Aimee S

Washington University
United States

Administrative Supplement to Building equity in cancer screening through research: The Siteman Catchment CSRN Hub 3UG1CA286946-02S1 Elyse LeeVan, M.D., M.P.H.
Jang, Mi-Hyeon

Rutgers Biomedical And Health Sciences
United States

Identification of novel biomarkers and therapeutic strategies in chemobrain. 5R01CA293210-02 John Clifford, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554