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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Herman, James G.

University Of Pittsburgh At Pittsburgh
United States

Optimizing Ultrasensitive DNA methylation detection for lung cancer and other malignancies 5U2CCA271885-04 Wendy Wang, Ph.D., M.Sc.
Herrmann, Joerg

Mayo Clinic Rochester
United States

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial 5R01CA233610-06 Eileen Dimond, R.N., M.S.
Herrmann, Joerg

Mayo Clinic Rochester
United States

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial 5R01CA233610-06 Eileen Dimond, R.N., M.S.
Hilakivi-Clarke, Leena A.

University Of Minnesota
United States

Effect of maternal obesity on breast cancer among offspring: role of the gut microbiota 5R01CA276775-03 Amit Kumar, Ph.D.
Hill, Joshua Aiden

Fred Hutchinson Cancer Center
United States

Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy 5R01CA276040-03 Nancy J. Emenaker, Ph.D., RDN, LD, FAND
Hitchins, Megan P

H. Lee Moffitt Cancer Ctr & Res Inst
United States

Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age 7R01CA252042-05 Matthew Young, Ph.D.
Hollingsworth, Michael A.

University Of Nebraska Medical Center
United States

Pancreatic Cancer Detection Consortium 5U01CA210240-09 Matthew Young, Ph.D.
Hoshida, Yujin

Ut Southwestern Medical Center
United States

Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis 4U01CA288375-03 Sidney Fu, M.D.
Houghton, A Mcgarry

Fred Hutchinson Cancer Center
United States

Tumor-specific autoantibodies for SCLC early detection 5R01CA243328-06 Guillermo Marquez, Ph.D.
Howitt, Brooke E

Stanford University
United States

Unraveling heterogeneity in endometrial cancer via integrated single cell genotype-phenotype mapping 1R37CA303960-01 Goli Samimi, Ph.D., M.P.H.
Hruska, Carrie B

Mayo Clinic Rochester
United States

Density MATTERS Clinical Trial 5R01CA239200-05 Claire Zhu, Ph.D.
Hsu, Li

Fred Hutchinson Cancer Center
United States

Statistical Methods for Precision Prevention 1R01CA297681-01 Claire Zhu, Ph.D.
Hu, Jim

Weill Medical Coll Of Cornell Univ
United States

Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL) 5R01CA259173-04 Marjorie Perloff, M.D.
Hu, Shuiying

Ohio State University
United States

Targeting neuronal transport to ameliorate vincristine neurotoxicity 5R01CA272254-03 Rachel Altshuler, Ph.D.
Hu, Jim

Weill Medical Coll Of Cornell Univ
United States

Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL) 5R01CA259173-04 Marjorie Perloff, M.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554