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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Friday, Bret E.B.

Essentia Institute Of Rural Health
United States

Essentia Health Community Cancer Research Program - NCORP 3UG1CA189812-11S1 Vanessa A. White, M.P.H.
Friday, Bret E.B.

Essentia Institute Of Rural Health
United States

Essentia Health Community Cancer Research Program - NCORP 3UG1CA189812-11S1 Vanessa A. White, M.P.H.
Furuta, Saori

Case Western Reserve University
United States

Normalizing arginine metabolism with sepiaptein for immunostimulatory-shift ofHER2+ breast cancer 5R01CA248304-05
Fuschiotti, Patrizia

University Of Pittsburgh At Pittsburgh
United States

Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides 5R21CA280445-02 Wendy Wang, Ph.D., M.Sc.
Garcia, Jose M.

Seattle Inst For Biomedical/Clinical Res
United States

SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT) 5R01CA279220-02 Marjorie Perloff, M.D.
Garcia, Jose M.

Seattle Inst For Biomedical/Clinical Res
United States

SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT) 5R01CA279220-02 Marjorie Perloff, M.D.
Geisler, Stefanie

Washington University
United States

Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy 5R37CA267905-04 Asad Umar, D.V.M., Ph.D.
Geisler, Stefanie

Washington University
United States

Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy 5R37CA267905-04 Asad Umar, D.V.M., Ph.D.
Germain, Doris A

Icahn School Of Medicine At Mount Sinai
United States

Investigating the efficacy of g-Tocotrienol for the prevention of post-partum breast cancer 1R01CA301372-01 Anda Vlad, M.D., Ph.D.
Germain, Doris A

Icahn School Of Medicine At Mount Sinai
United States

Exploring ovarian-derived hormone STC1 as the mediator of the protective effect of breast feeding against breast cancer. 5R21CA270702-02 Marjorie Perloff, M.D.
Ghamande, Sharad A.

Augusta University
United States

Georgia CaRes 3UG1CA189851-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ghamande, Sharad A.

Augusta University
United States

Georgia CaRes 3UG1CA189851-11S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Ghobrial, Irene M.

Dana-Farber Cancer Inst
United States

Myeloma multidimensional precancer atlas 4U01CA294507-02 Nicholas Hodges, Ph.D.
Ghobrial, Irene M.

Dana-Farber Cancer Inst
United States

Molecular prediction of myeloma in African Americans 5U01CA271492-04 Claire Zhu, Ph.D.
Ghosh, Jayashri

Temple Univ Of The Commonwealth
United States

Development of blood-based methylation biomarkers for CRC risk prediction 5R01CA281948-03 Matthew Young, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554