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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Faller, Bryan

Decatur Memorial Hospital
United States

Heartland Cancer Research NCORP 3UG1CA189830-11S1 Vanessa A. White, M.P.H.
Faller, Bryan

Decatur Memorial Hospital
United States

Heartland Cancer Research NCORP 3UG1CA189830-11S1 Vanessa A. White, M.P.H.
Farrar, Christian T

Massachusetts General Hospital
United States

Novel metabolomic contrast probes for human lung cancer characterization 4R01CA273010-04 Guillermo Marquez, Ph.D.
Feng, Ziding

Fred Hutchinson Cancer Center
United States

Consortium on Translational Research in Early Detection of Liver Cancer:Data Management and Coordinating Center (DMCC) 5U24CA230144-09 Guillermo Marquez, Ph.D.
Fiol, Guilherme Del

University Of Utah
United States

GARDE: Scalable Clinical Decision Support for Individualized Cancer Risk Management 5U24CA274582-03 Christos Patriotis, Ph.D., M.Sc.
Fitzgibbon, Marian L.

University Of Illinois At Chicago
United States

Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk 5R01CA250390-05 Young Kim, Ph.D.
Flory, James H

Sloan-Kettering Inst Can Research
United States

Managing metabolic disruption in pancreatic cancer to prevent weight loss and improve quality of life 5R21CA277464-02 Gabriela Riscuta, M.D., CNS
Flory, James H

Sloan-Kettering Inst Can Research
United States

Managing metabolic disruption in pancreatic cancer to prevent weight loss and improve quality of life 5R21CA277464-02 Gabriela Riscuta, M.D., CNS
Flowers, Lisa C.

Emory University
United States

Georgia Consortium to Eliminate Cervical Cancer in Women Living with HIV (GaCECC-WLWH) 5UG1CA284884-03 Maria Silvina Frech, Ph.D., M.S.
Flowers, Lisa C.

Emory University
United States

Screening Strategies Among High-Risk Populations for Anal Cancer 5R01CA285198-03 Vikrant Sahasrabuddhe, M.B.B.S., M.P.H., Dr.P.H.
Flynn, Kathryn E

Medical College Of Wisconsin
United States

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM) 5R01CA285925-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Flynn, Kathryn E

Medical College Of Wisconsin
United States

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM) 5R01CA285925-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Forsberg, Flemming

Thomas Jefferson University
United States

Prostate Cancer Diagnosis by Multiparametric Ultrasound 5R01CA252311-05
Frazier, Anne Lindsay

Dana-Farber Cancer Inst
United States

Assay Validation of a Circulating miRNA Test for Diagnosis and Monitoring of Malignant Germ Cell Tumors 5UH3CA240688-05 Nicholas Hodges, Ph.D.
Freedland, Stephen Jay

Cedars-Sinai Medical Center
United States

Intermittent Fasting using a Fasting-Mimetic Diet to Improve Prostate Cancer Control and Metabolic Outcomes 3R01CA280081-03S1 Young Kim, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554