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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Eldridge, Ronald C

Emory University
United States

Integrative Multi-Omics of Metabolomics and Epigenetics to Explore thePathophysiology of Cachexia and Survival in Head and Neck SquamousCell Carcinoma 1R03CA304028-01 Marjorie Perloff, M.D.
Eldridge, Ronald C

Emory University
United States

Integrative Multi-Omics of Metabolomics and Epigenetics to Explore thePathophysiology of Cachexia and Survival in Head and Neck SquamousCell Carcinoma 1R03CA304028-01 Marjorie Perloff, M.D.
Elenitoba-Johnson, Kojo S. J.

Sloan-Kettering Inst Can Research
United States

Genomic biomarkers of splenic lymphoma 5R01CA255655-06 Nicholas Hodges, Ph.D.
Elias, Kevin

Cleveland Clinic Lerner Com-Cwru
United States

Ovarian cancer risk stratification using circulating miRNAs to assess BRCAness 7R03CA283252-02 Christos Patriotis, Ph.D., M.Sc.
Ellerton, John A

Southern Nevada Cancer Research Fdn
United States

NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required) 3UG1CA189829-11S1 Vanessa A. White, M.P.H.
Ellerton, John A

Southern Nevada Cancer Research Fdn
United States

NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required) 3UG1CA189829-11S1 Vanessa A. White, M.P.H.
Ellsworth, Grant B.

Weill Medical Coll Of Cornell Univ
United States

Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico 3U54CA242639-06S3 Maria Silvina Frech, Ph.D., M.S.
Elmore, Joann G

University Of California Los Angeles
United States

Optimizing the Human-Computer Interaction in Pathology: Understanding the Impact of Computer-Aided Diagnosis Tools on Pathologists' Interpretive Performance 1R01CA288824-01A1 Claire Zhu, Ph.D.
Elswick, Ronald K

Virginia Commonwealth University
United States

A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer 5R01CA286799-03 Asad Umar, D.V.M., Ph.D.
Elswick, Ronald K

Virginia Commonwealth University
United States

A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer 5R01CA286799-03 Asad Umar, D.V.M., Ph.D.
Elswick, Ronald K

Virginia Commonwealth University
United States

A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer 5R01CA286799-03 Asad Umar, D.V.M., Ph.D.
Esserman, Laura J

University Of California, San Francisco
United States

WISDOM: A platform to optimize subtype-specific screening and prevention 5P01CA281826-02 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Esserman, Laura J

University Of California, San Francisco
United States

Extending the Diversity, Reach, and Generalizability of the WISDOM Study 5R01CA237533-05 Claire Zhu, Ph.D.
Fabian, Carol J.

University Of Kansas Medical Center
United States

Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer 5R01CA249437-05 Edward Sauter, M.D., Ph.D.
Fahrmann, Johannes F

University Of Tx Md Anderson Can Ctr
United States

Blood-Based Biomarkers for Personalized Risk Assessment of Breast and Ovarian Cancer 5U01CA282216-03 Claire Zhu, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554