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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About the Cancer Immunoprevention Network

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Demb, Joshua Brian

University Of California, San Diego
United States

Optimal early colorectal cancer screening initiation 4R00CA267181-03 Claire Zhu, Ph.D.
Demehri, Shadmehr

Massachusetts General Hospital
United States

Immunosurveillance of breast glands with oncogenic germline mutations 5UG3CA290300-02 Altaf Mohammed, Ph.D.
Deng, Jie

University Of Pennsylvania
United States

Placebo-Controlled Phase II Randomized Clinical Trial of Photobiomodulation Therapy in Head and Neck Cancer Survivors with Chronic Lymphedema 1R01CA289307-01A1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Deng, Gary E

University Of California-Irvine
United States

Acupuncture to Improve Outcomes in Patients with Sepsis: a Randomized Controlled Trial 7R21CA286330-03 Goli Samimi, Ph.D., M.P.H.
Deng, Youping

University Of Hawaii At Manoa
United States

Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms 5R01CA230514-05 Christos Patriotis, Ph.D., M.Sc.
Dhakal, Soma

Virginia Commonwealth University
United States

Single-Molecule High-Confidence Detection of miRNA Cancer Biomarkers 5R61CA278445-03 Christos Patriotis, Ph.D., M.Sc.
Diaz, Juan Sebastian Gomez

University Of California At Davis
United States

A miniaturized neural network enabled nanoplasmonic spectroscopy platform for label-free cancer detection in biofluids 3R01CA273253-03S1 Nicholas Hodges, Ph.D.
Dickinson, Sally E

University Of Arizona
United States

Investigating novel targets for topical immunoprevention of keratinocytic skin cancer 1UG3CA290443-01A1 Altaf Mohammed, Ph.D.
Digirolamo, Gregory James

Univ Of Massachusetts Med Sch Worcester
United States

Increasing Nodule Detection in Lung Cancer by Non-Conscious Detection of "Missed" Nodules and Machine Learning 5R01CA269903-04
Doescher, Mark P

University Of Oklahoma Hlth Sciences Ctr
United States

Oklahoma Tribal, Rural, Urban Cancer Screening Trial ACCESS Hub 3UG1CA287044-02S1 Elyse LeeVan, M.D., M.P.H.
Doolittle, Gary C.

University Of Kansas Medical Center
United States

The University of Kansas Cancer Center's- MCA Rural NCORP- extension 3UG1CA239767-06S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Doolittle, Gary C.

University Of Kansas Medical Center
United States

The University of Kansas Cancer Center's- MCA Rural NCORP- extension 3UG1CA239767-06S1 Brandy Heckman-Stoddard, Ph.D., M.P.H.
Drake, Richard R.

Medical University Of South Carolina
United States

Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues, Cells and Biofluids 5R33CA267226-03
Drescher, Charles

Swedish Medical Center, First Hill
United States

The Pacific Cancer Research Consortium (PCRC), an NCORP Community Site 3UG1CA189953-11S1 Vanessa A. White, M.P.H.
Drescher, Charles

Swedish Medical Center, First Hill
United States

The Pacific Cancer Research Consortium (PCRC), an NCORP Community Site 3UG1CA189953-11S1 Vanessa A. White, M.P.H.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554